Literature DB >> 12143003

ent-trachyloban-3beta-ol, a new cytotoxic diterpene from Croton zambesicus.

S Block, C Stévigny, M-C De Pauw-Gillet, E de Hoffmann, G Llabrès, V Adjakidjé, J Quetin-Leclercq.   

Abstract

The dichloromethane extract of leaves of Croton zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against human cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 microg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12143003     DOI： 10.1055/s-2002-32903

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

Review 1.  Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae).

Authors:  Kirkland Dingili Magwilu; Joseph Mwanzia Nguta; Isaac Mapenay; Dorine Matara
Journal:  Adv Pharmacol Pharm Sci       Date:  2022-05-17

2.  Synthesis of highly functionalised enantiopure bicyclo[3.2.1]- octane systems from carvone.

Authors:  Antonio Abad; Consuelo Agulló; Ana C Cuñat; Ignacio de Alfonso; Ismael Navarro; Noelia Vera
Journal:  Molecules       Date:  2004-04-30       Impact factor: 4.411

3.  Antiproliferative activity of flavonoids from Croton sphaerogynus Baill. (Euphorbiaceae).

Authors:  Kátia Pereira dos Santos; Lucimar B Motta; Deborah Y A C Santos; Maria L F Salatino; Antonio Salatino; Marcelo J Pena Ferreira; João Henrique G Lago; Ana Lúcia T G Ruiz; João E de Carvalho; Cláudia M Furlan
Journal:  Biomed Res Int       Date:  2015-05-17       Impact factor: 3.411

4.  Ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex Hutch. and Assessment of Their Cytotoxicity against Human Cancer Cell Lines.

Authors:  Stephanie Tamdem Guetchueng; Lutfun Nahar; Kenneth James Ritchie; Fyaz Mahmood Daud Ismail; Andrew Robert Evans; Satyajit Dey Sarker
Journal:  Molecules       Date:  2018-02-13       Impact factor: 4.411

5.  Croton gratissimus leaf extracts inhibit cancer cell growth by inducing caspase 3/7 activation with additional anti-inflammatory and antioxidant activities.

Authors:  Emmanuel Mfotie Njoya; Jacobus N Eloff; Lyndy J McGaw
Journal:  BMC Complement Altern Med       Date:  2018-11-14       Impact factor: 3.659

6.  Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species.

Authors:  Ashwell R Ndhlala; Mutalib A Aderogba; Bhekumthetho Ncube; Johannes Van Staden
Journal:  Molecules       Date:  2013-02-01       Impact factor: 4.411

7.  In vitro and in vivo antitumor effect of trachylobane-360, a diterpene from Xylopia langsdorffiana.

Authors:  João Carlos Lima Rodrigues Pita; Aline Lira Xavier; Tatyanna Kelvia Gomes de Sousa; Vivianne Mendes Mangueira; Josean Fechine Tavares; Robson José de Oliveira Júnior; Robson Cavalcante Veras; Hilzeth de Luna Freire Pessoa; Marcelo Sobral da Silva; Sandra Morelli; Veridiana de Melo Rodrigues Ávila; Teresinha Gonçalves da Silva; Margareth de Fátima Formiga Melo Diniz; Marianna Vieira Sobral Castello-Branco
Journal:  Molecules       Date:  2012-08-10       Impact factor: 4.411

8.  Cytotoxicity of naturally occurring phenolics and terpenoids from Kenyan flora towards human carcinoma cells.

Authors:  Victor Kuete; Leonidah K Omosa; Jacob O Midiwo; Oğuzhan Karaosmanoğlu; Hülya Sivas
Journal:  J Ayurveda Integr Med       Date:  2018-10-30
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.