| Literature DB >> 12142645 |
Karine Titier1, Fabrice Lagrange, Fabienne Péhourcq, Nicholas Moore, Mathieu Molimard.
Abstract
An 18-year-old man received two high-dose methotrexate cycles for the treatment of an osteosarcoma. Fifteen grams of methotrexate were infused over 6 hours. During the second cycle, co-administration of oxacillin (1g/8h) resulted in prolonged and marked elevation of methotrexate plasma concentrations. The patient experienced acute toxicity with renal failure, myelosuppression, mucitis, fever, and dermatologic abnormalities. After an initial improvement with folinic acid rescue and hemodialysis, the patient died. Oxacillin may thus inhibit the elimination of methotrexate.Entities:
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Year: 2002 PMID： 12142645 DOI： 10.1097/00007691-200208000-00018
Source DB: PubMed Journal: Ther Drug Monit ISSN： 0163-4356 Impact factor: 3.681