| Literature DB >> 12141877 |
Robert L Arslanian1, Li Tang, Shannon Blough, Wei Ma, Rong-Guo Qiu, Leonard Katz, John R Carney.
Abstract
A new epothilone, 10,11-didehydroepothilone D (5), was isolated from a strain of the heterologous host Myxococcus xanthus genetically engineered to produce epothilone D (4). The structure of 5 was determined from NMR and MS data. The epothilone polyketide synthase was further modified in a recombinant M. xanthus strain to produce 5 as the major epothilone-related metabolite. The cytotoxicity of 5 against a panel of tumor cell lines, including several with multidrug resistance, and its effect on tubulin polymerization were comparable to epothilone D (4).Entities:
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Year: 2002 PMID： 12141877 DOI： 10.1021/np020120f
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050