| Literature DB >> 12141869 |
Shugeng Cao1, Alex S Y Lee, Yicun Huang, Horst Flotow, Siewbee Ng, Mark S Butler, Antony D Buss.
Abstract
Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.Entities:
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Year: 2002 PMID： 12141869 DOI： 10.1021/np010626i
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050