PURPOSE: To assess whether an association exists between iris color and the incidence of cataract and cataract surgery. DESIGN: Population-based cohort study. METHODS: The Blue Mountains Eye Study examined 3654 predominantly Caucasian participants aged 49+ years during 1992-1994, and then 2335 survivors (75.1%) after 5 years. Iris color was determined by comparison with four standard photographs. Slit-lamp and retro-illumination lens photographs were graded for presence and severity of cortical, nuclear, or posterior subcapsular cataract. Incident cataract surgery was recorded by history and from the photographs. RESULTS: Participants with dark brown iris color had an increased incidence of nuclear cataract, odds ratio (OR) 1.8, 95% confidence interval (CI) 1.2 to 2.8, and cataract surgery (OR, 2.5; CI, 1.4-4.2) in multivariate models, compared with participants with blue iris color. CONCLUSION: Incidence data from this study support previous cross-sectional findings linking dark brown iris color with age-related cataract.
PURPOSE: To assess whether an association exists between iris color and the incidence of cataract and cataract surgery. DESIGN: Population-based cohort study. METHODS: The Blue Mountains Eye Study examined 3654 predominantly Caucasian participants aged 49+ years during 1992-1994, and then 2335 survivors (75.1%) after 5 years. Iris color was determined by comparison with four standard photographs. Slit-lamp and retro-illumination lens photographs were graded for presence and severity of cortical, nuclear, or posterior subcapsular cataract. Incident cataract surgery was recorded by history and from the photographs. RESULTS:Participants with dark brown iris color had an increased incidence of nuclear cataract, odds ratio (OR) 1.8, 95% confidence interval (CI) 1.2 to 2.8, and cataract surgery (OR, 2.5; CI, 1.4-4.2) in multivariate models, compared with participants with blue iris color. CONCLUSION: Incidence data from this study support previous cross-sectional findings linking dark brown iris color with age-related cataract.
Authors: Prethy Rao; Amy E Millen; Kristin J Meyers; Zhe Liu; Rickie Voland; Sheri Sondel; Lesley Tinker; Robert B Wallace; Barbara A Blodi; Neil Binkley; Gloria Sarto; Jennifer Robinson; Erin LeBlanc; Julie A Mares Journal: Invest Ophthalmol Vis Sci Date: 2015-07 Impact factor: 4.799
Authors: Christian Nischler; Ralph Michael; Christine Wintersteller; Patrick Marvan; Laurentius J van Rijn; Joris E Coppens; Thomas J T P van den Berg; Martin Emesz; Günther Grabner Journal: Graefes Arch Clin Exp Ophthalmol Date: 2012-04-12 Impact factor: 3.117
Authors: Gabriel Chodick; Nural Bekiroglu; Michael Hauptmann; Bruce H Alexander; D Michal Freedman; Michele Morin Doody; Li C Cheung; Steven L Simon; Robert M Weinstock; André Bouville; Alice J Sigurdson Journal: Am J Epidemiol Date: 2008-07-29 Impact factor: 4.897