Literature DB >> 12139954

Neuronal changes in normal human aging and Alzheimer's disease.

Harry B M Uylings1, J M de Brabander.   

Abstract

This article discusses age-related changes in brain weight, total number of cortical neurons, cortical dendrites, spine, and synapse density. The conclusion is that the present outlook is less grim than it was 30 years ago. Age-related reduction appears to be specific to brain region and cortical layer rather than a general feature. In addition, we describe a different pattern of changes that occur in Alzheimer's disease patients. This review concludes that the association cortices in particular are affected in aging and Alzheimer's disease and that the primary visual and somatosensory cortices are relatively spared.

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Year:  2002        PMID： 12139954     DOI： 10.1006/brcg.2001.1500

Source DB:  PubMed          Journal:  Brain Cogn        ISSN： 0278-2626            Impact factor:   2.310


  71 in total

1.  Age-related changes in neural volume and microstructure associated with interleukin-6 are ameliorated by a calorie-restricted diet in old rhesus monkeys.

Authors:  A A Willette; B B Bendlin; D G McLaren; E Canu; E K Kastman; K J Kosmatka; G Xu; A S Field; A L Alexander; R J Colman; R H Weindruch; C L Coe; S C Johnson
Journal:  Neuroimage       Date:  2010-03-15       Impact factor: 6.556

2.  rhEPO Enhances Cellular Anti-oxidant Capacity to Protect Long-Term Cultured Aging Primary Nerve Cells.

Authors:  Huqing Wang; Jiaxin Fan; Mengyi Chen; Qingling Yao; Zhen Gao; Guilian Zhang; Haiqin Wu; Xiaorui Yu
Journal:  J Mol Neurosci       Date:  2017-06-21       Impact factor: 3.444

3.  Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration.

Authors:  Faviola Alcantara-Gonzalez; Ismael Juarez; Oscar Solis; Isaura Martinez-Tellez; Israel Camacho-Abrego; Eliezer Masliah; Raul Mena; Gonzalo Flores
Journal:  Synapse       Date:  2010-10       Impact factor: 2.562

Review 4.  Cognitive aging and Alzheimer's disease.

Authors:  R Vandenberghe; J Tournoy
Journal:  Postgrad Med J       Date:  2005-06       Impact factor: 2.401

Review 5.  Differential aging of the brain: patterns, cognitive correlates and modifiers.

Authors:  Naftali Raz; Karen M Rodrigue
Journal:  Neurosci Biobehav Rev       Date:  2006-08-17       Impact factor: 8.989

6.  Efficient control of arm movements in advanced age.

Authors:  Gyusung Lee; Laetitia Fradet; Caroline J Ketcham; Natalia Dounskaia
Journal:  Exp Brain Res       Date:  2006-08-30       Impact factor: 1.972

Review 7.  Perturbations of neural circuitry in aging, mild cognitive impairment, and Alzheimer's disease.

Authors:  Stephanie L Leal; Michael A Yassa
Journal:  Ageing Res Rev       Date:  2013-02-04       Impact factor: 10.895

8.  Somatosensory responses in normal aging, mild cognitive impairment, and Alzheimer's disease.

Authors:  Julia M Stephen; Rebecca Montaño; Christopher H Donahue; John C Adair; Janice Knoefel; Clifford Qualls; Blaine Hart; Doug Ranken; Cheryl J Aine
Journal:  J Neural Transm (Vienna)       Date:  2009-12-15       Impact factor: 3.575

Review 9.  Glial cell dysregulation: a new perspective on Alzheimer disease.

Authors:  Rommy von Bernhardi
Journal:  Neurotox Res       Date:  2007-12       Impact factor: 3.911

10.  Dynamics of gray matter loss in Alzheimer's disease.

Authors:  Paul M Thompson; Kiralee M Hayashi; Greig de Zubicaray; Andrew L Janke; Stephen E Rose; James Semple; David Herman; Michael S Hong; Stephanie S Dittmer; David M Doddrell; Arthur W Toga
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167
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