| Literature DB >> 12139499 |
Kris Dumont1, Jessa Yperman, Erik Verbeken, Patrick Segers, Bart Meuris, Stijn Vandenberghe, Willem Flameng, Pascal R Verdonck.
Abstract
Evidence has been gathered that biomechanical factors have a significant impact on cell differentiation and behavior in in vitro cell cultures. The aim of this bioreactor is to create a physiological environment in which tissue engineered (TE) aortic valves seeded with human cells can be cultivated during a period of several days. The bioreactor consists of 2 major parts: the left ventricle (LV) and the afterload consisting of a compliance, representing the elastic function of the large arteries, and in series a resistance, mimicking the arterioles and capillaries. The TE aortic valve is placed between the LV and the compliance. With controllable resistance, compliance, stroke volume and frequency, and hydrodynamic conditions can be changed over a wide physiological range. This study resulted in a prototype of a compact pulsatile flow system for the creation of TE aortic valves. In addition a biocompatibility study of the used materials is performed.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12139499 DOI： 10.1046/j.1525-1594.2002.06931_3.x
Source DB: PubMed Journal: Artif Organs ISSN： 0160-564X Impact factor: 3.094