| Literature DB >> 12139441 |
Matthew F Leeman1, Stephanie Curran, Graeme I Murray.
Abstract
Matrix metalloproteinase-13 (MMP-13) is a proteolytic enzyme that belongs to a large family of extracellular matrix-degrading endopeptidases that are characterized by a zinc-binding motif at their catalytic sites. MMP-13 has a key role in the MMP activation cascade and appears to be critical in bone metabolism and homeostasis. It also has an important role in tumor invasion and metastasis. This commentary provides a detailed overview of the regulatory mechanisms, structure, and function of human MMP-13 and highlights the key factors involved in the biology of this important molecule.Entities:
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Year: 2002 PMID： 12139441 DOI： 10.1080/10409230290771483
Source DB: PubMed Journal: Crit Rev Biochem Mol Biol ISSN： 1040-9238 Impact factor: 8.250