Literature DB >> 12139434

Genetic association studies: design, analysis and interpretation.

Cathryn M Lewis1.   

Abstract

This paper provides a review of the design and analysis of genetic association studies. In case control studies, the different contingency tables and their relationships to the underlying genetic model are defined. Population stratification is discussed, with suggested methods to identify and correct for the effect. The transmission disequilibrium test is provided as an alternative family-based test, which is robust to population stratification. The relative benefits of each analysis are summarised.

Mesh：

Year:  2002        PMID： 12139434     DOI： 10.1093/bib/3.2.146

Source DB:  PubMed          Journal:  Brief Bioinform        ISSN： 1467-5463            Impact factor:   11.622


  131 in total

1.  The future of association studies: gene-based analysis and replication.

Authors:  Benjamin M Neale; Pak C Sham
Journal:  Am J Hum Genet       Date:  2004-07-22       Impact factor: 11.025

2.  Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals.

Authors:  Tatjana Sjakste; Natalia Paramonova; Kristine Osina; Kristine Dokane; Jelizaveta Sokolovska; Nikolajs Sjakste
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3.  SNPs and prognosis of GvHD before HCT: any progress?

Authors:  M I Abu Zaid; S Paczesny; D B Miklos
Journal:  Bone Marrow Transplant       Date:  2015-10-12       Impact factor: 5.483

Review 4.  Genes and human elite athletic performance.

Authors:  Daniel G Macarthur; Kathryn N North
Journal:  Hum Genet       Date:  2005-02-22       Impact factor: 4.132

5.  No association of the NFKB1 promoter polymorphism with ulcerative colitis in a British case control cohort.

Authors:  M M Mirza; S A Fisher; C Onnie; C M Lewis; C G Mathew; J Sanderson; A Forbes
Journal:  Gut       Date:  2005-08       Impact factor: 23.059

6.  Association mapping of agronomic traits on chromosome 2A of wheat.

Authors:  Ji Yao; Lixin Wang; Lihua Liu; Changping Zhao; Yonglian Zheng
Journal:  Genetica       Date:  2009-01-23       Impact factor: 1.082

7.  A single nucleotide polymorphism of PLIN2 is associated with nonalcoholic steatohepatitis and causes phenotypic changes in hepatocyte lipid droplets: A pilot study.

Authors:  Claire S Faulkner; Collin M White; Vijay H Shah; Loretta L Jophlin
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2020-01-23       Impact factor: 4.698

8.  IL28B rs12979860 genotype and spontaneous clearance of hepatitis C virus in a multi-ethnic cohort of injection drug users: evidence for a supra-additive association.

Authors:  Fatma M Shebl; Ruth M Pfeiffer; Dianna Buckett; Brian Muchmore; Sabrina Chen; Myhanh Dotrang; Ludmila Prokunina-Olsson; Brian R Edlin; Thomas R O'Brien
Journal:  J Infect Dis       Date:  2011-10-19       Impact factor: 5.226

9.  Gene polymorphisms of fibronectin rs2289202 and fibrillin 2 rs331069 associate with vascular disease, the TAMRISK study.

Authors:  Tarja Kunnas; Tiina Solakivi; Seppo T Nikkari
Journal:  Biomed Rep       Date:  2017-11-17

10.  Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population.

Authors:  Hyun-Kyung Park; Dong Hwan Kim; Dong Hwan Yun; Ju Yeon Ban
Journal:  Mol Biol Rep       Date:  2012-10-21       Impact factor: 2.316
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