Literature DB >> 12138981

Clinical, microbiological, and economic benefit of a change in antibiotic prophylaxis for cardiac surgery.

Denis Spelman1, Glenys Harrington, Phil Russo, S Wesselingh.   

Abstract

Vancomycin and rifampicin replaced cephazolin as antibiotic prophylaxis for coronary artery bypass surgery at our institution. Following this intervention, there was a significant decrease (P < .001) in the surgical-site infection rate from 10.5 (95% confidence interval, 8.2 to 13.3) to 4.9 (95% confidence interval, 3.2 to 7.1) infections per 100 procedures. An estimated $576,655 (Australian) was saved between two 12-month periods.

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Year:  2002        PMID： 12138981     DOI： 10.1086/502074

Source DB:  PubMed          Journal:  Infect Control Hosp Epidemiol        ISSN： 0899-823X            Impact factor:   3.254


  5 in total

1.  Comparison of clinical and economic outcomes of two antibiotic prophylaxis regimens for sternal wound infection in high-risk patients following coronary artery bypass grafting surgery: a prospective randomised double-blind controlled trial.

Authors:  Kay Dhadwal; Sharif Al-Ruzzeh; Thanos Athanasiou; Marina Choudhury; Paris Tekkis; Pynee Vuddamalay; Haifa Lyster; Mohamed Amrani; Shane George
Journal:  Heart       Date:  2007-02-19       Impact factor: 5.994

2.  Interrupted time series analysis of vancomycin compared to cefuroxime for surgical prophylaxis in patients undergoing cardiac surgery.

Authors:  K W Garey; D Lai; T K Dao-Tran; L O Gentry; L Y Hwang; B R Davis
Journal:  Antimicrob Agents Chemother       Date:  2007-11-19       Impact factor: 5.191

3.  Combination prophylactic therapy with rifampin increases efficacy against an experimental Staphylococcus epidermidis subcutaneous implant-related infection.

Authors:  Alexandra I Stavrakis; Jared A Niska; Jonathan H Shahbazian; Amanda H Loftin; Romela Irene Ramos; Fabrizio Billi; Kevin P Francis; Michael Otto; Nicholas M Bernthal; Daniel Z Uslan; Lloyd S Miller
Journal:  Antimicrob Agents Chemother       Date:  2014-02-10       Impact factor: 5.191

4.  Multicentre randomised double-blind placebo controlled trial of combination vancomycin and cefazolin surgical antibiotic prophylaxis: the Australian surgical antibiotic prophylaxis (ASAP) trial.

Authors:  Trisha Peel; Sarah Astbury; Allen C Cheng; David Paterson; Kirsty Buising; Tim Spelman; An Tran-Duy; Richard S de Steiger
Journal:  BMJ Open       Date:  2019-11-03       Impact factor: 2.692

Review 5.  Effectiveness of a bundled intervention of decolonization and prophylaxis to decrease Gram positive surgical site infections after cardiac or orthopedic surgery: systematic review and meta-analysis.

Authors:  Marin Schweizer; Eli Perencevich; Jennifer McDanel; Jennifer Carson; Michelle Formanek; Joanne Hafner; Barbara Braun; Loreen Herwaldt
Journal:  BMJ       Date:  2013-06-13
  5 in total

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