OBJECTIVES: Different dielectric properties of cancerous tissues are correlated with increased conductance potentially measurable using Electrical Impedance Scanning (EIS). Sonographically based differentiation of lesions in the salivary glands remains difficult. The clinical value of EIS used additionally to Ultrasound was investigated. METHODS: Sonographically suspicious lesions of parotid (n = 25) and submandibular (n = 16) glands were examined using TransScan TS2000 (TransScan Medical, Israel; distributed by Siemens, Sweden). Bright focal spots representing areas of high conductance were read as positive; absence of a focal spot (ie, homogeneous gray) was read as negative. All lesions were histopathologically proved. RESULTS: 14/15 malignant (93.3%) and 13/26 benign lesions (50.0%) were correctly detected using EIS, NPV 93%, PPV 52%. All cases of squamous cell carcinoma were correctly identified. Lymph node relapse of T-cell lymphoma, lymph node relapse of malignant melanoma, malignant hemangioendothelioma and 2/3 adenocystic carcinoma (primary metastases) were correctly detected. CONCLUSIONS: Our initial results suggest EIS to be of interest when used adjunctively to ultrasound for the identification of malignant lesions of the salivary glands. However, low specificity induced in part by current technical restrictions (bone interference, skin alterations, contact artifacts, prominence of the lesions) limit this clinical application.
OBJECTIVES: Different dielectric properties of cancerous tissues are correlated with increased conductance potentially measurable using Electrical Impedance Scanning (EIS). Sonographically based differentiation of lesions in the salivary glands remains difficult. The clinical value of EIS used additionally to Ultrasound was investigated. METHODS: Sonographically suspicious lesions of parotid (n = 25) and submandibular (n = 16) glands were examined using TransScan TS2000 (TransScan Medical, Israel; distributed by Siemens, Sweden). Bright focal spots representing areas of high conductance were read as positive; absence of a focal spot (ie, homogeneous gray) was read as negative. All lesions were histopathologically proved. RESULTS: 14/15 malignant (93.3%) and 13/26 benign lesions (50.0%) were correctly detected using EIS, NPV 93%, PPV 52%. All cases of squamous cell carcinoma were correctly identified. Lymph node relapse of T-cell lymphoma, lymph node relapse of malignant melanoma, malignant hemangioendothelioma and 2/3 adenocystic carcinoma (primary metastases) were correctly detected. CONCLUSIONS: Our initial results suggest EIS to be of interest when used adjunctively to ultrasound for the identification of malignant lesions of the salivary glands. However, low specificity induced in part by current technical restrictions (bone interference, skin alterations, contact artifacts, prominence of the lesions) limit this clinical application.
Authors: Hans-Joachim Mentzel; Ansgar Malich; Karim Kentouche; Martin Freesmeyer; Joachim Böttcher; Gerlind Schneider; Bernd Gruhn; Susanna Vogt; Felix Zintl; Roselle Anderson; Werner A Kaiser Journal: Pediatr Radiol Date: 2003-05-01
Authors: Jacqueline Dinnes; Lavinia Ferrante di Ruffano; Yemisi Takwoingi; Seau Tak Cheung; Paul Nathan; Rubeta N Matin; Naomi Chuchu; Sue Ann Chan; Alana Durack; Susan E Bayliss; Abha Gulati; Lopa Patel; Clare Davenport; Kathie Godfrey; Manil Subesinghe; Zoe Traill; Jonathan J Deeks; Hywel C Williams Journal: Cochrane Database Syst Rev Date: 2019-07-01