Literature DB >> 12137756

Role and activation of type III secretion system genes in Pseudomonas aeruginosa-induced Drosophila killing.

M-O Fauvarque1, E Bergeret, J Chabert, D Dacheux, M Satre, I Attree.   

Abstract

Pseudomonas aeruginosa strains PAO1 and CHA showing type III system-dependent cytotoxicity towards macrophages ex vivo are able to induce rapid death of adult fly Drosophila melanogaster accompanied by bacterial multiplication to high-titers. The role of P. aeruginosa type III secretion system in rapid fly killing was demonstrated here by using several isogenic CHA mutants, selectively affected in this system. The activation of P. aeruginosa pexsCBA, the regulatory operon of the type III system, and the activation of the Drosophila gene diptericin, showed the host-pathogen recognition during infection process.

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Year:  2002        PMID： 12137756     DOI： 10.1006/mpat.2002.0504

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  36 in total

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5.  Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species.

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9.  Drosophila melanogaster as a model host for the Burkholderia cepacia complex.

Authors:  Josée Castonguay-Vanier; Ludovic Vial; Julien Tremblay; Eric Déziel
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