Literature DB >> 12137411

Irampanel Boehringer Ingelheim.

Valery Feigin1.   

Abstract

The oxazole derivative, irampanel, a non-competitive AMPA receptor antagonist, is under development by Boehringer Ingelheim for the potential treatment of stroke [329079]. Phase I/IIa trials for stroke had been initiated by July 2000 [374144]. Phase II trials were ongoing in April 2001 [407163]; in April 2002, however, the drug did not appear on the company's research and development pipeline [446554], and a company spokesperson declined to confirm its current status [450591]. The compound was also originally under investigation for other neurological disorders, including epilepsy and pain [329079], although by October 1999, development was only ongoing for stroke [346080].

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12137411

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  4 in total

1.  Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate.

Authors:  Emmanuel H Demont; Benjamin I Andrews; Rino A Bit; Colin A Campbell; Jason W B Cooke; Nigel Deeks; Sapna Desai; Simon J Dowell; Pam Gaskin; James R J Gray; Andrea Haynes; Duncan S Holmes; Umesh Kumar; Mary A Morse; Greg J Osborne; Terry Panchal; Bela Patel; Alcide Perboni; Simon Taylor; Robert Watson; Jason Witherington; Robert Willis
Journal:  ACS Med Chem Lett       Date:  2011-03-24       Impact factor: 4.345

2.  Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.

Authors:  Zhen Chen; Wakana Mori; Xiaofei Zhang; Tomoteru Yamasaki; Patrick J Dunn; Genwei Zhang; Hualong Fu; Tuo Shao; Yiding Zhang; Akiko Hatori; Longle Ma; Masayuki Fujinaga; Lin Xie; Xiaoyun Deng; Hua Li; Qingzhen Yu; Jian Rong; Lee Josephson; Jun-An Ma; Yihan Shao; Susumu Tomita; Ming-Rong Zhang; Steven H Liang
Journal:  Eur J Med Chem       Date:  2018-08-09       Impact factor: 6.514

3.  Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors.

Authors:  Jiahui Chen; Jiefeng Gan; Jiyun Sun; Zhen Chen; Hualong Fu; Jian Rong; Xiaoyun Deng; Jingjie Shang; Jian Gong; Tuo Shao; Lee Collier; Lu Wang; Hao Xu; Steven H Liang
Journal:  Tetrahedron Lett       Date:  2020-01-17       Impact factor: 2.415

4.  Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors.

Authors:  Gengyang Yuan; Graham B Jones; Neil Vasdev; Steven H Liang
Journal:  Bioorg Med Chem Lett       Date:  2016-08-09       Impact factor: 2.823
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.