| Literature DB >> 12136242 |
Rogério Grimaldi1, Nice Shindo, Angelina Xavier Acosta, Inês Dourado, Carlos Brites, Ozenilda de Melo Carvalho, Ivo Brito, Dumith Chequer Bou-Habib, Bernardo Galvão-Castro.
Abstract
We investigated the occurrence of the CCR5Delta32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Delta32/Delta32). German descendents were 11% heterozygous and l% Delta32/Delta32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.Entities:
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Year: 2002 PMID： 12136242 DOI： 10.1007/s00439-002-0747-x
Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132