BACKGROUND: Subtle disorders of neuronal migration occur in the brains of some dyslexic patients who presented developmental language disorder (DLD) during early childhood. OBJECTIVE: To investigate a possible neuroanatomical substrate based on neuroimaging evaluation in children with DLD. METHODS: The authors obtained psychological assessment, language evaluation, neurologic examination, and neuroimaging investigation. Inclusion criteria were as follows: children should be at least 4 years of age; primary complaint of language delay; normal hearing; IQ >70; and an informed consent form signed by parents or guardians. Exclusion criteria were severe motor and cognitive handicap. RESULTS: Fifteen children met all inclusion criteria. Ages ranged from 4 to 14 years and 11 were boys. Six patients presented diffuse polymicrogyria (PMG) around the entire extent of the sylvian fissure on MRI, and they had severe clinical manifestation of DLD: they did not speak at all or had mixed phonologic-syntactic deficit syndrome. Six children presented PMG restricted to the posterior aspects of the parietal regions, and they had a milder form of DLD: mainly phonologic programming deficit syndrome. The other three children had different imaging findings. CONCLUSIONS: Developmental language disorder can be associated with polymicrogyria and the clinical manifestation varies according to the extension of cortical abnormality. A subtle form of posterior parietal polymicrogyria presenting as developmental language disorder is a mild form of perisylvian syndrome.
BACKGROUND:Subtle disorders of neuronal migration occur in the brains of some dyslexic patients who presented developmental language disorder (DLD) during early childhood. OBJECTIVE: To investigate a possible neuroanatomical substrate based on neuroimaging evaluation in children with DLD. METHODS: The authors obtained psychological assessment, language evaluation, neurologic examination, and neuroimaging investigation. Inclusion criteria were as follows: children should be at least 4 years of age; primary complaint of language delay; normal hearing; IQ >70; and an informed consent form signed by parents or guardians. Exclusion criteria were severe motor and cognitive handicap. RESULTS: Fifteen children met all inclusion criteria. Ages ranged from 4 to 14 years and 11 were boys. Six patients presented diffuse polymicrogyria (PMG) around the entire extent of the sylvian fissure on MRI, and they had severe clinical manifestation of DLD: they did not speak at all or had mixed phonologic-syntactic deficit syndrome. Six children presented PMG restricted to the posterior aspects of the parietal regions, and they had a milder form of DLD: mainly phonologic programming deficit syndrome. The other three children had different imaging findings. CONCLUSIONS:Developmental language disorder can be associated with polymicrogyria and the clinical manifestation varies according to the extension of cortical abnormality. A subtle form of posterior parietal polymicrogyria presenting as developmental language disorder is a mild form of perisylvian syndrome.
Authors: Kiho Im; Rudolph Pienaar; Michael J Paldino; Nadine Gaab; Albert M Galaburda; P Ellen Grant Journal: Cereb Cortex Date: 2012-09-17 Impact factor: 5.357
Authors: Clarissa L Yasuda; Catarina A Guimarães; Marilisa M Guerreiro; Mirela Boscariol; Ecila P M Oliveira; Karine C Teixeira; André L F Costa; Guilherme C Beltramini; Fernando Cendes Journal: J Neurol Date: 2014-04-30 Impact factor: 4.849
Authors: Steven W Threlkeld; Courtney A Hill; Caitlin E Szalkowski; Dongnhu T Truong; Glenn D Rosen; R Holly Fitch Journal: Behav Brain Res Date: 2012-07-31 Impact factor: 3.332
Authors: Richard S Smith; Connor J Kenny; Vijay Ganesh; Ahram Jang; Rebeca Borges-Monroy; Jennifer N Partlow; R Sean Hill; Taehwan Shin; Allen Y Chen; Ryan N Doan; Anna-Kaisa Anttonen; Jaakko Ignatius; Livija Medne; Carsten G Bönnemann; Jonathan L Hecht; Oili Salonen; A James Barkovich; Annapurna Poduri; Martina Wilke; Marie Claire Y de Wit; Grazia M S Mancini; Laszlo Sztriha; Kiho Im; Dina Amrom; Eva Andermann; Ritva Paetau; Anna-Elina Lehesjoki; Christopher A Walsh; Maria K Lehtinen Journal: Neuron Date: 2018-08-23 Impact factor: 17.173