| Literature DB >> 12135438 |
S E Grams1, P V Moonsamy, C Mano, J R Oksenberg, A B Begovich.
Abstract
HLA-B typing of approximately 1 262 individuals from a study of 372 simplex families with multiple sclerosis has led to the identification of two new alleles (HLA-B*4422 and HLA-B*4704). Sequencing confirmed that both of these new alleles represent novel combinations of previously described sequence motifs, reinforcing the notion that recombination and/or gene conversion-like events play an important role in generating HLA allelic diversity. The identification of these new alleles brings the total number of HLA-B alleles to 465.Entities:
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Year: 2002 PMID： 12135438 DOI： 10.1034/j.1399-0039.2002.590417.x
Source DB: PubMed Journal: Tissue Antigens ISSN： 0001-2815