| Literature DB >> 12132898 |
Ronan Bureau1, Cyril Daveu, Stéphane Lemaître, François Dauphin, Henriette Landelle, Jean-Charles Lancelot, Sylvain Rault.
Abstract
A definition of a pharmacophore for the 5-HT4 antagonist was carried out by considering a three-dimensional model which correlates the chemical structures of series of antagonists with their biological affinities. A molecular design is described by analyzing the differences between two 3D serotonin pharmacophores. This successful structural modification demonstrates the efficiency of this approach to design new serotonin ligands.Entities:
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Year: 2002 PMID： 12132898 DOI： 10.1021/ci0101354
Source DB: PubMed Journal: J Chem Inf Comput Sci ISSN： 0095-2338