BACKGROUND: Cytokines play an important role in modulating inflammatory and proliferative responses, including atherosclerosis. Transforming growth factor-beta (TGF-beta) and macrophage-colony stimulating factor (M-CSF) are one of the major antiinflammatory and proinflammatory cytokines, respectively. We have previously demonstrated that plasma concentrations of TGF-beta are decreased while those of M-CSF are increased in patients with coronary artery disease (CAD). In this study, we examined whether those alterations in plasma levels of cytokines have a prognostic significance in patients with CAD. METHODS AND RESULTS: Sixty-eight consecutive patients with proven CAD were studied. The plasma concentrations of TGF-beta and those of M-CSF were measured by enzyme-linked immunosorbent assay (ELISA). They were divided into groups: high (> or =6 ng/ml, n = 19) and low (<6 ng/ml, n = 49) TGF-beta groups and high (>500 ng/ml, n = 52) and low (< or =500 ng/ml, n = 16) M-CSF groups. The long-term prognosis of these patients was prospectively followed up for a mean period of 979 +/- 27 days. The prognosis was analyzed by Kaplan-Meier analysis in terms of total survival, survival without myocardial infarction, survival without cardiovascular events and survival without coronary interventions. The analysis showed that the low TGF-beta group had a significantly poor prognosis in terms of survival without cardiovascular events and survival without coronary interventions as compared with the high TGF-beta group (both P < 0.05), while other prognoses were comparable between the two groups. By contrast, no significant prognostic influence was noted regarding M-CSF. CONCLUSIONS: These results suggest that plasma concentrations of TGF-beta may have a prognostic significance in patients with CAD.
BACKGROUND: Cytokines play an important role in modulating inflammatory and proliferative responses, including atherosclerosis. Transforming growth factor-beta (TGF-beta) and macrophage-colony stimulating factor (M-CSF) are one of the major antiinflammatory and proinflammatory cytokines, respectively. We have previously demonstrated that plasma concentrations of TGF-beta are decreased while those of M-CSF are increased in patients with coronary artery disease (CAD). In this study, we examined whether those alterations in plasma levels of cytokines have a prognostic significance in patients with CAD. METHODS AND RESULTS: Sixty-eight consecutive patients with proven CAD were studied. The plasma concentrations of TGF-beta and those of M-CSF were measured by enzyme-linked immunosorbent assay (ELISA). They were divided into groups: high (> or =6 ng/ml, n = 19) and low (<6 ng/ml, n = 49) TGF-beta groups and high (>500 ng/ml, n = 52) and low (< or =500 ng/ml, n = 16) M-CSF groups. The long-term prognosis of these patients was prospectively followed up for a mean period of 979 +/- 27 days. The prognosis was analyzed by Kaplan-Meier analysis in terms of total survival, survival without myocardial infarction, survival without cardiovascular events and survival without coronary interventions. The analysis showed that the low TGF-beta group had a significantly poor prognosis in terms of survival without cardiovascular events and survival without coronary interventions as compared with the high TGF-beta group (both P < 0.05), while other prognoses were comparable between the two groups. By contrast, no significant prognostic influence was noted regarding M-CSF. CONCLUSIONS: These results suggest that plasma concentrations of TGF-beta may have a prognostic significance in patients with CAD.
Authors: Isha Agarwal; Nicole L Glazer; Eddy Barasch; Mary L Biggs; Luc Djousse; Annette L Fitzpatrick; John S Gottdiener; Joachim H Ix; Jorge R Kizer; Eric B Rimm; David S Sicovick; Russell P Tracy; Kenneth J Mukamal Journal: Circ Arrhythm Electrophysiol Date: 2014-06-24
Authors: Andrew D Frutkin; Goro Otsuka; April Stempien-Otero; Casilde Sesti; Liang Du; Mia Jaffe; Helén L Dichek; Caroline J Pennington; Dylan R Edwards; Madeline Nieves-Cintrón; Daniel Minter; Michael Preusch; Jie Hong Hu; Julien C Marie; David A Dichek Journal: Arterioscler Thromb Vasc Biol Date: 2009-03-26 Impact factor: 8.311