OBJECTIVE: To evaluate the effect of mild hypothermia on the relationship between systemic oxygen consumption and oxygen delivery. DESIGN: Prospective animal study. SETTING: University research laboratory. SUBJECTS: Anesthetized and ventilated rabbits. INTERVENTIONS: Rabbits were subjected to stepwise cardiac tamponade to reduce oxygen delivery while body temperature was maintained at 34 degrees C (group H, n = 8) or 39 degrees C (group N, n = 8). MEASUREMENTS AND MAIN RESULTS: The oxygen consumption/oxygen delivery relationship was analyzed by the dual-line method. The slope of the supply-dependent line was significantly decreased in group H (y = 0.57x + 1.3) compared with that in group N (y = 0.72x + 1.7), indicating that the ability of tissues to extract oxygen was impaired during hypothermia. Consequently, the proportion of the supply-independent area over the entire range of oxygen delivery was decreased in response to hypothermia. CONCLUSION: The potential for tissue hypoxia is likely to be increased during hypothermia when the circulation becomes unstable and oxygen delivery decreases.
OBJECTIVE: To evaluate the effect of mild hypothermia on the relationship between systemic oxygen consumption and oxygen delivery. DESIGN: Prospective animal study. SETTING: University research laboratory. SUBJECTS: Anesthetized and ventilated rabbits. INTERVENTIONS:Rabbits were subjected to stepwise cardiac tamponade to reduce oxygen delivery while body temperature was maintained at 34 degrees C (group H, n = 8) or 39 degrees C (group N, n = 8). MEASUREMENTS AND MAIN RESULTS: The oxygen consumption/oxygen delivery relationship was analyzed by the dual-line method. The slope of the supply-dependent line was significantly decreased in group H (y = 0.57x + 1.3) compared with that in group N (y = 0.72x + 1.7), indicating that the ability of tissues to extract oxygen was impaired during hypothermia. Consequently, the proportion of the supply-independent area over the entire range of oxygen delivery was decreased in response to hypothermia. CONCLUSION: The potential for tissue hypoxia is likely to be increased during hypothermia when the circulation becomes unstable and oxygen delivery decreases.