Literature DB >> 1213048

The absence of an inhibitory effect of metyrapone (2-methyl-1,2-di (3-pyridyl) propan-1-one) on hepatic microsomal hydroxylation in scurvy.

A M Fielding, R E Hughes.   

Abstract

Microsomes from livers of scorbutic guinea-pigs showed a reduced rate of acetanilide hydroxylation. The response of "scorbutic" liver microsomes to the inhibitor Metyrapone (2-methyl-1,2 di (3-pyridyl) propan-1-one) was different from that of liver microsomes from non-scorbutic guinea-pigs.

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Year:  1975        PMID： 1213048     DOI： 10.1007/bf01923204

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Metabolic interactions between L-ascorbic acid and drugs.

Authors:  A H CONNEY; G A BRAY; C EVANS; J J BURNS
Journal:  Ann N Y Acad Sci       Date:  1961-04-21       Impact factor: 5.691

2.  [Research on enzymatic hydroxylation. Hydroxylation of acetanilid and its relation to microsomal pyridine nucleotide oxidation].

Authors:  K KRISCH; H STAUDINGER
Journal:  Biochem Z       Date:  1961

3.  The use of homocysteine in the estimation of dehydroascorbic acid.

Authors:  R E HUGHES
Journal:  Biochem J       Date:  1956-09       Impact factor: 3.857

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Effects of metyrapone on liver microsomal drug oxidations.

Authors:  K C Leibman
Journal:  Mol Pharmacol       Date:  1969-01       Impact factor: 4.436

6.  Dietary protein, growth and retention of ascorbic acid in guinea-pigs.

Authors:  R S Williams; R E Hughes
Journal:  Br J Nutr       Date:  1972-09       Impact factor: 3.718

7.  Ascorbic acid in aromatic hydroxylation. III. Effect of ascorbic acid on hydroxylation of acetanilide, aniline and antipyrine in vivo.

Authors:  J AXELROD; S UDENFRIEND; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1954-06       Impact factor: 4.030
  7 in total
  1 in total

1.  Nonscorbutic effects of vitamin C: biochemical aspects.

Authors:  R E Hughes
Journal:  Proc R Soc Med       Date:  1977-02
  1 in total

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