BACKGROUND: Childhood bipolarity (BP) and ADHD frequently co-occur, these children often receive stimulants. METHOD: We retrospectively evaluated 80 adolescents hospitalized with BP, manic or mixed, assessed severity of hospital course, and compared groups according to current/past stimulant or antidepressant treatment. RESULTS: Lifetime ADHD rate was 49%; 35% of patients had exposure to stimulants and 44% to antidepressants. Stimulant-exposed patients were younger than non-exposed (mean+/-S.D.=13.7+/-2 vs. 15.1+/-2 years, Z=-3.1, P=0.002). Only stimulant exposure was associated with worse hospitalization course (MANCOVA, Wilks' Lambda=0.87, F=3.4; df=70; P=0.02). CONCLUSION: Stimulant-exposed BP-adolescents may have more severe illness course not fully explained by ADHD comorbidity. LIMITATIONS: Retrospective methodology and lack of structured interviewing make it difficult to quantify exposure to stimulants and antidepressants. Copright 2002 Elsevier Science BV.
BACKGROUND: Childhood bipolarity (BP) and ADHD frequently co-occur, these children often receive stimulants. METHOD: We retrospectively evaluated 80 adolescents hospitalized with BP, manic or mixed, assessed severity of hospital course, and compared groups according to current/past stimulant or antidepressant treatment. RESULTS: Lifetime ADHD rate was 49%; 35% of patients had exposure to stimulants and 44% to antidepressants. Stimulant-exposed patients were younger than non-exposed (mean+/-S.D.=13.7+/-2 vs. 15.1+/-2 years, Z=-3.1, P=0.002). Only stimulant exposure was associated with worse hospitalization course (MANCOVA, Wilks' Lambda=0.87, F=3.4; df=70; P=0.02). CONCLUSION: Stimulant-exposed BP-adolescents may have more severe illness course not fully explained by ADHD comorbidity. LIMITATIONS: Retrospective methodology and lack of structured interviewing make it difficult to quantify exposure to stimulants and antidepressants. Copright 2002 Elsevier Science BV.
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