| Literature DB >> 12127986 |
Yoichiro Yoshida1, Hiroto Izumi, Tomoko Ise, Hidetaka Uramoto, Takayuki Torigoe, Hiroshi Ishiguchi, Tadashi Murakami, Mizuho Tanabe, Yoshifumi Nakayama, Hideaki Itoh, Hiroshi Kasai, Kimitoshi Kohno.
Abstract
Mitochondrial transcription factor A (mtTFA) is necessary for both transcription and maintenance of mtDNA, and is also one of the high mobility group (HMG) proteins that preferentially binds to cisplatin-damaged DNA. In this study we confirmed the preferential binding of mtTFA to cisplatin-damaged DNA, and also discovered that mtTFA binds to oxidatively damaged DNA. The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG. Our findings suggest that mtTFA plays an important role in the recognition of oxidative DNA damage.Entities:
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Year: 2002 PMID： 12127986 DOI： 10.1016/s0006-291x(02)00757-x
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575