Literature DB >> 12127867

'Omic' and hypothesis-driven research in the molecular pharmacology of cancer.

John N Weinstein1.   

Abstract

Given the layered, evolutionary complexity of biological systems, it will not be possible to understand them comprehensively on the basis of hypothesis-driven research alone. Likewise, it will not be possible to do so solely through 'omic' studies of genes, proteins and other molecules in aggregate. The two modes of research are complementary and synergistic. The twin complexities of cancer biology and drug discovery demand such synergy as a basis for the next generation of oncopharmacomic research.

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Mesh：

Year:  2002        PMID： 12127867     DOI： 10.1016/s1471-4892(02)00185-6

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  17 in total

1.  Drug discovery: Cell lines battle cancer.

Authors:  John N Weinstein
Journal:  Nature       Date:  2012-03-28       Impact factor: 49.962

2.  Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery.

Authors:  Roberto Romero; Shali Mazaki-Tovi; Edi Vaisbuch; Juan Pedro Kusanovic; Tinnakorn Chaiworapongsa; Ricardo Gomez; Jyh Kae Nien; Bo Hyun Yoon; Moshe Mazor; Jingqin Luo; David Banks; John Ryals; Chris Beecher
Journal:  J Matern Fetal Neonatal Med       Date:  2010-05-26

Review 3.  The use of high-dimensional biology (genomics, transcriptomics, proteomics, and metabolomics) to understand the preterm parturition syndrome.

Authors:  R Romero; J Espinoza; F Gotsch; J P Kusanovic; L A Friel; O Erez; S Mazaki-Tovi; N G Than; S Hassan; G Tromp
Journal:  BJOG       Date:  2006-12       Impact factor: 6.531

4.  Biomedical ontologies in action: role in knowledge management, data integration and decision support.

Authors:  O Bodenreider
Journal:  Yearb Med Inform       Date:  2008

5.  The reductionist paradox: are the laws of chemistry and physics sufficient for the discovery of new drugs?

Authors:  Gerald M Maggiora
Journal:  J Comput Aided Mol Des       Date:  2011-06-23       Impact factor: 3.686

6.  Comprehensive evaluation of the contribution of X chromosome genes to platinum sensitivity.

Authors:  Eric R Gamazon; Hae Kyung Im; Peter H O'Donnell; Dana Ziliak; Amy L Stark; Nancy J Cox; M Eileen Dolan; Rong Stephanie Huang
Journal:  Mol Cancer Ther       Date:  2011-01-20       Impact factor: 6.261

7.  Multifactorial regulation of E-cadherin expression: an integrative study.

Authors:  William C Reinhold; Mark A Reimers; Philip Lorenzi; Jennifer Ho; Uma T Shankavaram; Micah S Ziegler; Kimberly J Bussey; Satoshi Nishizuka; Ogechi Ikediobi; Yves G Pommier; John N Weinstein
Journal:  Mol Cancer Ther       Date:  2010-01-06       Impact factor: 6.261

8.  The placenta in preeclampsia.

Authors:  James M Roberts; C Escudero
Journal:  Pregnancy Hypertens       Date:  2012-04-01       Impact factor: 2.899

9.  Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays.

Authors:  Satoshi Nishizuka; Lu Charboneau; Lynn Young; Sylvia Major; William C Reinhold; Mark Waltham; Hosein Kouros-Mehr; Kimberly J Bussey; Jae K Lee; Virginia Espina; Peter J Munson; Emanuel Petricoin; Lance A Liotta; John N Weinstein
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205

10.  Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.

Authors:  R Stephanie Huang; Sharon E Johnatty; Eric R Gamazon; Hae Kyung Im; Dana Ziliak; Shiwei Duan; Wei Zhang; Emily O Kistner; Peixian Chen; Jonathan Beesley; Shuangli Mi; Peter H O'Donnell; Yarden S Fraiman; Soma Das; Nancy J Cox; Yi Lu; Stuart Macgregor; Ellen L Goode; Robert A Vierkant; Brooke L Fridley; Estrid Hogdall; Susanne K Kjaer; Allan Jensen; Kirsten B Moysich; Matthew Grasela; Kunle Odunsi; Robert Brown; Jim Paul; Diether Lambrechts; Evelyn Despierre; Ignace Vergote; Jenny Gross; Beth Y Karlan; Anna Defazio; Georgia Chenevix-Trench; M Eileen Dolan
Journal:  Clin Cancer Res       Date:  2011-06-24       Impact factor: 12.531
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