Literature DB >> 12127744

Sealed with a twist: complexin and the synaptic SNARE complex.

Karla E Marz1, Phyllis I Hanson.   

Abstract

Knockout experiments show that complexins are crucial for Ca(2+)-dependent neurotransmitter release. In the recently solved crystal structure of complexin I bound to the synaptic SNARE complex, complexin binds along the groove between the syntaxin and synaptobrevin coils. This structure, together with NMR data, suggests that the role of complexin is to stabilize the SNARE complex as it forms from SNAREs in vesicle and target membranes.

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Year:  2002        PMID： 12127744     DOI： 10.1016/s0166-2236(02)02207-5

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  9 in total

1.  A new platform to study the molecular mechanisms of exocytosis.

Authors:  Aviv Mezer; Esther Nachliel; Menachem Gutman; Uri Ashery
Journal:  J Neurosci       Date:  2004-10-06       Impact factor: 6.167

2.  Single-molecule studies of synaptotagmin and complexin binding to the SNARE complex.

Authors:  Mark E Bowen; Keith Weninger; James Ernst; Steven Chu; Axel T Brunger
Journal:  Biophys J       Date:  2005-04-08       Impact factor: 4.033

Review 3.  Tag team action at the synapse.

Authors:  Chavela M Carr; Mary Munson
Journal:  EMBO Rep       Date:  2007-09       Impact factor: 8.807

4.  Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus.

Authors:  Mathias Zink; Simone Rapp; Peter J Gebicke-Haerter; Fritz A Henn; Johannes Thome
Journal:  Psychopharmacology (Berl)       Date:  2005-10-12       Impact factor: 4.530

Review 5.  Gene targeting of presynaptic proteins in synaptic plasticity and memory: across the great divide.

Authors:  Craig M Powell
Journal:  Neurobiol Learn Mem       Date:  2005-10-14       Impact factor: 2.877

6.  An electrostatically preferred lateral orientation of SNARE complex suggests novel mechanisms for driving membrane fusion.

Authors:  Ting Guo; Lin-Chen Gong; Sen-Fang Sui
Journal:  PLoS One       Date:  2010-01-26       Impact factor: 3.240

7.  Proteomic analysis reveals differentially expressed proteins in the rat frontal cortex after methamphetamine treatment.

Authors:  J J Faure; S M Hattingh; D J Stein; W M Daniels
Journal:  Metab Brain Dis       Date:  2009-10-14       Impact factor: 3.584

8.  Distribution of plasma membrane-associated syntaxins 1 through 4 indicates distinct trafficking functions in the synaptic layers of the mouse retina.

Authors:  David M Sherry; Robert Mitchell; Kelly M Standifer; Brad du Plessis
Journal:  BMC Neurosci       Date:  2006-07-13       Impact factor: 3.288

Review 9.  Single-molecule studies of the neuronal SNARE fusion machinery.

Authors:  Axel T Brunger; Keith Weninger; Mark Bowen; Steven Chu
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643
  9 in total

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