Literature DB >> 12127716

Smad7: a new key player in TGF-beta-associated disease.

Atsuhito Nakao, Ko Okumura, Hideoki Ogawa.   

Abstract

Smad7 is a major inhibitory regulator of transforming growth factor (TGF)-beta signaling. Smad7 expression is induced by TGF-beta itself and other signaling pathways, indicating a key role for Smad7 in feedback or cross-talk control of TGF-beta signaling. Recent reports have implicated Smad7 as a crucial regulator of TGF-beta activity in human disease; aberrant expression of Smad7 is involved in inflammatory bowel disease and scleroderma. Thus, modulation of Smad7 expression could provide a novel therapeutic basis for TGF-beta-associated disorders.

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Year:  2002        PMID： 12127716     DOI： 10.1016/s1471-4914(02)02376-6

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  15 in total

1.  MicroRNA-21 in scleroderma fibrosis and its function in TGF-β-regulated fibrosis-related genes expression.

Authors:  Honglin Zhu; Hui Luo; Yisha Li; Yaou Zhou; Ying Jiang; Jin Chai; Xianzhong Xiao; Yunhui You; Xiaoxia Zuo
Journal:  J Clin Immunol       Date:  2013-05-09       Impact factor: 8.317

2.  Evidence for an Important Role of Smad-7 in Intervertebral Disc Degeneration.

Authors:  Bo Li; Yi-Jun Su; Xin-Feng Zheng; Yue-Hua Yang; Sheng-Dan Jiang; Lei-Sheng Jiang
Journal:  J Interferon Cytokine Res       Date:  2015-03-26       Impact factor: 2.607

3.  Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-β signaling.

Authors:  Navin K Verma; Eugene Dempsey; Aideen Long; Anthony Davies; Sean P Barry; Padraic G Fallon; Yuri Volkov; Dermot Kelleher
Journal:  J Biol Chem       Date:  2012-06-15       Impact factor: 5.157

4.  MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.

Authors:  Xing He; Yue Sun; Nanhang Lei; Xiaobin Fan; Cheng Zhang; Yange Wang; Kuiyang Zheng; Dongmei Zhang; Weiqing Pan
Journal:  Proc Natl Acad Sci U S A       Date:  2017-12-18       Impact factor: 11.205

5.  Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.

Authors:  Taihao Quan; Tianyuan He; John J Voorhees; Gary J Fisher
Journal:  J Biol Chem       Date:  2004-12-03       Impact factor: 5.157

6.  Ex vivo transfer of Smad7 decreases damage to the corneal endothelium after penetrating keratoplasty.

Authors:  Toshinari Funaki; Nobuyuki Ebihara; Akira Murakami; Atsuhito Nakao
Journal:  Jpn J Ophthalmol       Date:  2008-07-27       Impact factor: 2.447

7.  Angiotensin II Receptor Antagonism Reduces Transforming Growth Factor Beta and Smad Signaling in Thoracic Aortic Aneurysm.

Authors:  Maria Nataatmadja; Jennifer West; Sulistiana Prabowo; Malcolm West
Journal:  Ochsner J       Date:  2013

8.  Smad3 knock-out mice as a useful model to study intestinal fibrogenesis.

Authors:  Giuliana Zanninelli; Antonella Vetuschi; Roberta Sferra; Angela D'Angelo; Amato Fratticci; Maria Adelaide Continenza; Maria Chiaramonte; Eugenio Gaudio; Renzo Caprilli; Giovanni Latella
Journal:  World J Gastroenterol       Date:  2006-02-28       Impact factor: 5.742

9.  C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21.

Authors:  Hao Wu; Lili Kong; Yi Tan; Paul N Epstein; Jun Zeng; Junlian Gu; Guang Liang; Maiying Kong; Xiangmei Chen; Lining Miao; Lu Cai
Journal:  Diabetologia       Date:  2016-04-26       Impact factor: 10.122

10.  Role of transforming growth factor-beta signaling pathway in pathogenesis of benign biliary stricture.

Authors:  Zhi-Min Geng; Jian-Bao Zheng; Xiao-Xue Zhang; Jie Tao; Lin Wang
Journal:  World J Gastroenterol       Date:  2008-08-21       Impact factor: 5.742
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