| Literature DB >> 12127554 |
Roberto P Falcão1, Aglair B Garcia, Maria G Marques, Belinda P Simões, Benedito A Fonseca, Miriam L Rodrigues, Norma T Foss.
Abstract
We report the findings of three new cases of a distinct clinicopathologic natural killer (NK) cell malignancy characterized by cutaneous, nodal and bone marrow infiltration by CD3-CD4+CD56+ NK blastic cells. Tumor cells were detected in bone marrow and in peripheral blood smears and showed finely distributed nuclear chromatin with nucleoli and a moderate amount of cytoplasm. Epstein-Barr virus (EBV) DNA was negative in the two tested cases. The immunophenotypes determined by flow cytometry were identical concerning mCD3-cytCD3-CD4+weakCD56+ HLA-DR+. The TCR was in germline configuration in the two cases tested. NK cell activity was demonstrated only in one out of the two cases tested. The negative reactions with alpha-naphthyl-acetate-esterase (ANAE), CD11b and CD14 strongly suggested that the tumor cells were not of the monocytic lineage.Entities:
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Year: 2002 PMID： 12127554 DOI： 10.1016/s0145-2126(02)00014-0
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156