Literature DB >> 12127537

Design and synthesis of novel inhibitors of gelatinase B.

Xueqing Wang1, Youngchool Choe, Charles S Craik, Jonathan A Ellman.   

Abstract

A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC(50)=13 microM.

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Year:  2002        PMID： 12127537     DOI： 10.1016/s0960-894x(02)00365-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

Review 1.  Understanding Tetrahydropyranyl as a Protecting Group in Peptide Chemistry.

Authors:  Anamika Sharma; Iván Ramos-Tomillero; Ayman El-Faham; Ernesto Nicolas; Hortensia Rodriguez; Beatriz G de la Torre; Fernando Albericio
Journal:  ChemistryOpen       Date:  2017-03-08       Impact factor: 2.911

Review 2.  Multidimensional Contribution of Matrix Metalloproteinases to Atherosclerotic Plaque Vulnerability: Multiple Mechanisms of Inhibition to Promote Stability.

Authors:  Jean Marie Ruddy; John S Ikonomidis; Jeffrey A Jones
Journal:  J Vasc Res       Date:  2016-06-22       Impact factor: 1.934

Review 3.  Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis.

Authors:  Sheikh Mohammed Arif; R Andres Floto; Tom L Blundell
Journal:  Front Mol Biosci       Date:  2022-03-30

4.  Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells.

Authors:  Alisha T Poole; Christopher A Sitko; Caitlin Le; Christian C Naus; Bryan M Hill; Eric A C Bushnell; Vincent C Chen
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  4 in total

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