Literature DB >> 12127521

3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists.

Jun Yuan1, Michael Gulianello, Stéphane De Lombaert, Robbin Brodbeck, Andrzej Kieltyka, Kevin J Hodgetts.   

Abstract

The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated.

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Year:  2002        PMID： 12127521     DOI： 10.1016/s0960-894x(02)00358-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs.

Authors:  Cuihua Wang; Trent D Ashton; Alden Gustafson; Nicholas D Bland; Stefan O Ochiana; Robert K Campbell; Michael P Pollastri
Journal:  Bioorg Med Chem Lett       Date:  2012-02-09       Impact factor: 2.823

2.  A novel strategy to assemble the beta-diketo acid pharmacophore of HIV integrase inhibitors on purine nucleobase scaffolds.

Authors:  Vinod Uchil; Byung Seo; Vasu Nair
Journal:  J Org Chem       Date:  2007-10-05       Impact factor: 4.354

3.  Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation.

Authors:  Spyridon Dimitrakis; Efthymios-Spyridon Gavriil; Athanasios Pousias; Nikolaos Lougiakis; Panagiotis Marakos; Nicole Pouli; Katerina Gioti; Roxane Tenta
Journal:  Molecules       Date:  2021-12-31       Impact factor: 4.411
  3 in total

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