Literature DB >> 12127518

The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class.

Richard J Sciotti1, Marina Pliushchev, Paul E Wiedeman, Darlene Balli, Robert Flamm, Angela M Nilius, Kennan Marsh, DeAnne Stolarik, Robert Jolly, Roger Ulrich, Stevan W Djuric.   

Abstract

A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.

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Year:  2002        PMID： 12127518     DOI： 10.1016/s0960-894x(02)00352-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones.

Authors:  E E McKee; M Ferguson; A T Bentley; T A Marks
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

2.  Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.

Authors:  Tamara V Milosevic; Valéry L Payen; Pierre Sonveaux; Giulio G Muccioli; Paul M Tulkens; Françoise Van Bambeke
Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

3.  Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis.

Authors:  Eva E Nagiec; Luping Wu; Steve M Swaney; John G Chosay; Daniel E Ross; Joan K Brieland; Karen L Leach
Journal:  Antimicrob Agents Chemother       Date:  2005-09       Impact factor: 5.191

4.  Stereodivergent Alkyne Hydrofluorination Using Protic Tetrafluoroborates as Tunable Reagents.

Authors:  Rui Guo; Xiaotian Qi; Hengye Xiang; Paul Geaneotes; Ruihan Wang; Peng Liu; Yi-Ming Wang
Journal:  Angew Chem Int Ed Engl       Date:  2020-07-14       Impact factor: 15.336

5.  Palladium-Catalyzed Defluorinative Coupling of 1-Aryl-2,2-Difluoroalkenes and Boronic Acids: Stereoselective Synthesis of Monofluorostilbenes.

Authors:  Richard T Thornbury; F Dean Toste
Journal:  Angew Chem Int Ed Engl       Date:  2016-08-11       Impact factor: 15.336

6.  Cyclodimers and Cyclotrimers of 2,3 -Bisalkynylated Anthracenes, Phenazines and Diazatetracenes.

Authors:  Steffen Maier; Nikolai Hippchen; Frank Rominger; Jan Freudenberg; Uwe H F Bunz
Journal:  Chemistry       Date:  2021-11-05       Impact factor: 5.020

7.  Platinum-Catalyzed Hydrofluorination of Alkynes: Hydrogen Bonding to Indolylphosphine Ligands to Provide Fluoride Reactivity.

Authors:  Stefan Sander; Thomas Braun
Journal:  Angew Chem Int Ed Engl       Date:  2022-05-26       Impact factor: 16.823
  7 in total

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