Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.

Literature DB >> 12127514

Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.

Bertrand Cottineau¹, Patrick Toto, Christophe Marot, Aline Pipaud, Jacques Chenault.

Abstract

The synthesis and in vivo activities of a series of substituted pyrazole-4-carboxylic acids as hypoglycemic agents are described. Modelization of some potent compounds, comparatively to the metformine, presents certain analogies permitting to predict the design of some novel antidiabetic drugs.

Entities: Chemical

Mesh：

Substances：

Year: 2002 PMID： 12127514 DOI： 10.1016/s0960-894x(02)00380-3

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

30 in total

1. Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.

Authors: Sana Aslam; Matloob Ahmad; Muhammad Zia-Ur-Rehman; Catherine Montero; Mervi Detorio; Masood Parvez; Raymond F Schinazi
Journal: Arch Pharm Res Date: 2013-07-10 Impact factor: 4.946

2. Design and synthesis of new imidazo[1,2-b]pyrazole derivatives, in vitro α-glucosidase inhibition, kinetic and docking studies.

Authors: Fariba Peytam; Mehdi Adib; Reihaneh Shourgeshty; Maryam Mohammadi-Khanaposhtani; Mehdi Jahani; Somaye Imanparast; Mohammad Ali Faramarzi; Mohammad Mahdavi; Ali Akbar Moghadamnia; Hossein Rastegar; Bagher Larijani
Journal: Mol Divers Date: 2019-03-02 Impact factor: 2.943

Review 3. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

Authors: Khalid Karrouchi; Smaail Radi; Youssef Ramli; Jamal Taoufik; Yahia N Mabkhot; Faiz A Al-Aizari; M'hammed Ansar
Journal: Molecules Date: 2018-01-12 Impact factor: 4.411

4. Immunomodulatory effects of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone from Petasites hybridus and its synthesized benzoxazepine derivatives.

Authors: Fatemeh Khaleghi; Ibrahim Jantan; Laily Bin Din; Wan A Yaacob; Mohammad A Khalilzadeh; Syed Nasir Abbas Bukhari
Journal: J Nat Med Date: 2013-10-24 Impact factor: 2.343

10. 3-(4-Chloro-phen-yl)-1-[(E)-1-(4-chloro-phen-yl)-2-(4-methyl-phenyl-sulfan-yl)ethen-yl]-4-(4-methyl-phenyl-sulfan-yl)-1H-pyrazole.

Authors: P Ramesh; Ramaiyan Manikannan; S Muthusubramanian; S S Sundaresan; M N Ponnuswamy
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2009-10-28

Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.

1. Synthesis and anti-HIV-1 screening of novel N'-(1-(aryl)ethylidene)-2-(5,5-dioxido-3-phenylbenzo[e]pyrazolo[4,3-c][1,2]thiazin-4(1H)-yl)acetohydrazides.

2. Design and synthesis of new imidazo[1,2-b]pyrazole derivatives, in vitro α-glucosidase inhibition, kinetic and docking studies.

Review 3. Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review.

4. Immunomodulatory effects of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone from Petasites hybridus and its synthesized benzoxazepine derivatives.

5. 1-(2,4-Dinitro-phenyl)-3-(4-methyl-phenyl)-4-phenyl-sulfanyl-1H-pyrazole.

6. (E)-3-(4-Bromo-phen-yl)-3-[3-(4-bromo-phen-yl)-1H-pyrazol-1-yl]prop-2-enal.

7. 1-{5-[4-(Hex-yloxy)phen-yl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}ethanone.

8. Ethyl 5-amino-1-(4-chloro-2-nitro-phen-yl)-1H-pyrazole-4-carboxyl-ate.

9. (E)-3-Phenyl-3-(3-phenyl-1H-1-pyrazol-yl)-2-propenal.

10. 3-(4-Chloro-phen-yl)-1-[(E)-1-(4-chloro-phen-yl)-2-(4-methyl-phenyl-sulfan-yl)ethen-yl]-4-(4-methyl-phenyl-sulfan-yl)-1H-pyrazole.