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Literature DB >> 12127243

In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid.

J-T Banzouzi¹, R Prado, H Menan, A Valentin, C Roumestan, M Mallie, Y Pelissier, Y Blache.

Abstract

Extracts of leaves of Alchornea cordifolia were studied for their antiplasmodial activities. Chloroformic and ether extracts were found to be inactive while the ethanolic extract exhibited mild in vitro activity against Plasmodium falciparum. Fractionation of this extract led us to isolate ellagic acid as the active constituent of the extract with IC(50) in the range of 0.2-0.5 microM. Cytotoxicity of ethanolic fraction and ellagic acid was also estimated on human fibroblasts cells (IC(50) on Hela cells = 7.3 microM at 24 h for ellagic acid).

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Year: 2002 PMID： 12127243 DOI： 10.1016/s0378-8741(02)00121-6

Source DB: PubMed Journal: J Ethnopharmacol ISSN： 0378-8741 Impact factor: 4.360

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Cited

20 in total

1. Antiplasmodial activity of botanical extracts against Plasmodium falciparum.

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2. Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.

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Journal: J Ethnopharmacol Date: 2013-01-02 Impact factor: 4.360

3. In vitro antiplasmodial activity of some medicinal plants of Burkina Faso.

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Journal: Parasitol Res Date: 2013-12-08 Impact factor: 2.289

4. Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells.

Authors: Yuki Hagiwara; Takashi Kasukabe; Yasuhiko Kaneko; Nozomi Niitsu; Junko Okabe-Kado
Journal: Int J Hematol Date: 2010-06-18 Impact factor: 2.490

In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent: ellagic acid.

1. Antiplasmodial activity of botanical extracts against Plasmodium falciparum.

2. Immunomodulatory activity of polysaccharides isolated from Alchornea cordifolia.

3. In vitro antiplasmodial activity of some medicinal plants of Burkina Faso.

4. Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells.

5. In vitro antimalarial activity of medicinal plant extracts against Plasmodium falciparum.

6. The ethnomedicine of the Haya people of Bugabo ward, Kagera Region, north western Tanzania.

7. In vitro and in vivo properties of ellagic acid in malaria treatment.

8. Compounds structurally related to ellagic acid show improved antiplasmodial activity.

9. The antimalarial potential of medicinal plants used for the treatment of malaria in Cameroonian folk medicine.

10. Implication of glutathione in the in vitro antiplasmodial mechanism of action of ellagic acid.