| Literature DB >> 12126438 |
David R Appleton1, Michael J Page, Gretchen Lambert, Michael V Berridge, Brent R Copp.
Abstract
Kottamides A-D (1-4), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian Pycnoclavella kottae and structurally characterized using 15N natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines.Entities:
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Year: 2002 PMID： 12126438 DOI： 10.1021/jo0201427
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354