OBJECTIVE: To elucidate the radiation effect on the normal brain after stereotactic radiosurgery (SRS), we evaluated the change in regional cerebral blood flow (CBF) in targeted and extra-targeted areas according to the radiation dose given. METHODS: Thirteen patients who underwent SRS for brain tumors or arteriovenous malformations were included in this study. Maximum radiation doses to the lesion ranged from 24 to 37 Gy. Mean and regional CBF were measured by 99mTc-HMPAO scintigraphy with graphic analysis, performed at before, 2 weeks and 3 months (5 patients) after SRS. Under the co-registration with the CT with superimposed isodose distribution, ROIs were set on target (37-20 Gy), peri-target (20-5 Gy) and out-of-field (5-2 Gy and less than 2 Gy) areas on the quantitative SPECT images. RESULTS: Significant reductions in mean CBF (by 7%) and regional CBF in the peri-target areas (by 5-7%) and out-of-field areas (by 6-22%) were recognized at 2 weeks and 3 months after SRS. Regional CBF in the target and peri-target areas did not significantly change, presumably because there was little or no normal tissue in these areas. CONCLUSION: These results suggest that subclinical regional CBF reduction occurs after SRS in the normal brain in out-of-field of radiation.
OBJECTIVE: To elucidate the radiation effect on the normal brain after stereotactic radiosurgery (SRS), we evaluated the change in regional cerebral blood flow (CBF) in targeted and extra-targeted areas according to the radiation dose given. METHODS: Thirteen patients who underwent SRS for brain tumors or arteriovenous malformations were included in this study. Maximum radiation doses to the lesion ranged from 24 to 37 Gy. Mean and regional CBF were measured by 99mTc-HMPAO scintigraphy with graphic analysis, performed at before, 2 weeks and 3 months (5 patients) after SRS. Under the co-registration with the CT with superimposed isodose distribution, ROIs were set on target (37-20 Gy), peri-target (20-5 Gy) and out-of-field (5-2 Gy and less than 2 Gy) areas on the quantitative SPECT images. RESULTS: Significant reductions in mean CBF (by 7%) and regional CBF in the peri-target areas (by 5-7%) and out-of-field areas (by 6-22%) were recognized at 2 weeks and 3 months after SRS. Regional CBF in the target and peri-target areas did not significantly change, presumably because there was little or no normal tissue in these areas. CONCLUSION: These results suggest that subclinical regional CBF reduction occurs after SRS in the normal brain in out-of-field of radiation.
Authors: Tiina Maria Remes; Maria Helena Suo-Palosaari; Päivi K T Koskenkorva; Anna K Sutela; Sanna-Maria Toiviainen-Salo; Pekka M Arikoski; Mikko O Arola; Vesa-Pekka Heikkilä; Mika Kapanen; Päivi Maria Lähteenmäki; Tuula R I Lönnqvist; Hannele Niiniviita; Tytti M-L Pokka; Liisa Porra; V Pekka Riikonen; Jan Seppälä; Kirsti H Sirkiä; Antti Vanhanen; Heikki M J Rantala; Arja H Harila-Saari; Marja K Ojaniemi Journal: Neurooncol Pract Date: 2020-02-07
Authors: Junie P Warrington; Nicole Ashpole; Anna Csiszar; Yong Woo Lee; Zoltan Ungvari; William E Sonntag Journal: J Vasc Res Date: 2013-10-01 Impact factor: 1.934
Authors: Line Brennhaug Nilsen; Ingrid Digernes; Endre Grøvik; Cathrine Saxhaug; Anna Latysheva; Oliver Geier; Birger Breivik; Dag Ottar Sætre; Kari Dolven Jacobsen; Åslaug Helland; Kyrre Eeg Emblem Journal: Neurooncol Adv Date: 2020-02-28
Authors: Jan Petr; Louise Hogeboom; Pavel Nikulin; Evita Wiegers; Gwen Schroyen; Jesper Kallehauge; Marek Chmelík; Patricia Clement; Ruben E Nechifor; Liviu-Andrei Fodor; Philip C De Witt Hamer; Frederik Barkhof; Cyril Pernet; Maarten Lequin; Sabine Deprez; Radim Jančálek; Henk J M M Mutsaerts; Francesca B Pizzini; Kyrre E Emblem; Vera C Keil Journal: MAGMA Date: 2021-12-17 Impact factor: 2.310
Authors: Raphael Jakubovic; Arjun Sahgal; Mark Ruschin; Ana Pejović-Milić; Rachael Milwid; Richard I Aviv Journal: Technol Cancer Res Treat Date: 2015-08