Literature DB >> 12124639

Development of insulin resistance in experimental animals during long-term glucocorticoid treatment.

V G Selyatitskaya1, O I Kuz'minova, S V Odintsov.   

Abstract

Long-term treatment with glucocorticoids led to the development of insulin resistance in experimental animals, which was confirmed by a progressive increase in blood insulin level and decrease in the glucose/insulin index. The comparative study showed that hydrocortisone produced more pronounced and rapid changes than dexamethasone. However, we found no differences in the glucose/insulin index by the 23rd day of treatment with these hormones.

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Year:  2002        PMID: 12124639     DOI: 10.1023/a:1016281501423

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  3 in total

1.  The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series.

Authors:  Richard R Almon; Debra C DuBois; William H Piel; William J Jusko
Journal:  Pharmacogenomics       Date:  2004-07       Impact factor: 2.533

2.  Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats.

Authors:  Jing Fang; Debra C DuBois; Yang He; Richard R Almon; William J Jusko
Journal:  J Pharmacokinet Pharmacodyn       Date:  2011-03-11       Impact factor: 2.745

3.  Comparison of the efficacy of cardamom (Elettaria cardamomum) with pioglitazone on dexamethasone-induced hepatic steatosis, dyslipidemia, and hyperglycemia in albino rats.

Authors:  G M Nitasha Bhat; Nagendra Nayak; K Vinodraj; N Chandralekha; Paul Mathai; J Cherian
Journal:  J Adv Pharm Technol Res       Date:  2015 Jul-Sep
  3 in total

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