Literature DB >> 12123600

Head, neck, and spines: a role for LIMK-1 in the hippocampus.

Patrick D Sarmiere1, James R Bamburg.   

Abstract

LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings are consistent with a role for LIMK-1 in synapse formation and function.

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Year:  2002        PMID： 12123600     DOI： 10.1016/s0896-6273(02)00759-6

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  6 in total

1.  The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.

Authors:  Baris Tursun; Anne Schlüter; Marvin A Peters; Birte Viehweger; Heather P Ostendorff; Juliana Soosairajah; Alexander Drung; Michael Bossenz; Steven A Johnsen; Michaela Schweizer; Ora Bernard; Ingolf Bach
Journal:  Genes Dev       Date:  2005-10-01       Impact factor: 11.361

2.  LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin.

Authors:  Genevieve S Yuen; Bruce S McEwen; Keith T Akama
Journal:  Brain Res       Date:  2010-08-07       Impact factor: 3.252

3.  Estrogen and aging affect synaptic distribution of phosphorylated LIM kinase (pLIMK) in CA1 region of female rat hippocampus.

Authors:  M Yildirim; W G M Janssen; N E Tabori; M M Adams; G S Yuen; K T Akama; B S McEwen; T A Milner; J H Morrison
Journal:  Neuroscience       Date:  2008-01-12       Impact factor: 3.590

4.  Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton.

Authors:  Hui Min; Jing Dong; Yi Wang; Yuan Wang; Ye Yu; Zhongyan Shan; Qi Xi; Weiping Teng; Jie Chen
Journal:  Mol Neurobiol       Date:  2016-01-07       Impact factor: 5.590

5.  Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway.

Authors:  Jun-Bum Park; Sameer Agnihotri; Brian Golbourn; Kelsey C Bertrand; Amanda Luck; Nesrin Sabha; Christian A Smith; Sara Byron; Gelareh Zadeh; Sidney Croul; Michael Berens; James T Rutka
Journal:  Oncotarget       Date:  2014-10-15

6.  Spine impairment in mice high-expressing neuregulin 1 due to LIMK1 activation.

Authors:  Peng Chen; Hongyang Jing; Mingtao Xiong; Qian Zhang; Dong Lin; Dongyan Ren; Shunqi Wang; Dongmin Yin; Yongjun Chen; Tian Zhou; Baoming Li; Erkang Fei; Bing-Xing Pan
Journal:  Cell Death Dis       Date:  2021-04-14       Impact factor: 8.469
  6 in total

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