Literature DB >> 12123367

An expedient route to the tetrazole analogues of alpha-amino acids.

Zachary P Demko1, K Barry Sharpless.   

Abstract

[reaction: see text] Convenient conditions are described for the transformation of alpha-aminonitriles to the tetrazole analogues of alpha-amino acids. Refluxing the starting material in water/2-propanol at 80 degrees C with sodium azide and catalytic zinc bromide affords the tetrazole product in yields generally exceeding 90%.

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Year:  2002        PMID： 12123367     DOI： 10.1021/ol020096x

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

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6.  α-Amino Acid-Isosteric α-Amino Tetrazoles.

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Authors:  Minghong Zhong; Scott A Strobel
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  9 in total

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