| Literature DB >> 12123359 |
Fraser F Fleming1, Zhiyu Zhang, Qunzhao Wang, Omar W Steward.
Abstract
[reaction: see text] omega-Chloro Grignard reagents chelate with cyclic gamma-hydroxy-alpha,beta-alkenenitriles to trigger a conjugate addition-alkylation annulation. The chelation-controlled conjugate addition-alkylation is the first anionic annulation with alpha, beta-alkenenitriles, providing cis bicyclo[3.3.0]octane, hydrindane, and decalin ring systems in a single synthetic operation.Entities:
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Year: 2002 PMID： 12123359 DOI： 10.1021/ol0261175
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005