D R Boniface1, M E Tefft. 1. University of Hertfordshire, Hatfield, Herts, UK. d.r.boniface@herts.ac.uk
Abstract
OBJECTIVE: The paper aims to investigate the relationships of dietary fats to subsequent coronary heart disease (CHD) mortality in men and women while taking account of other CHD-related behaviours. DESIGN: A cohort of randomly selected men and women were interviewed in 1984-85 and monitored subsequently for 16 y for deaths. The interview covered health, health-related behaviours, physical measurements, socio-demographic details and a dietary questionnaire. Appropriate exclusions left 1225 men and 1451 women aged 40-75 with 98 and 57 CHD deaths, respectively. Saturated, polyunsaturated and total fat intakes were estimated. SETTING: The sample was randomly selected from households in Great Britain. The interviews took place in participants' own homes. RESULTS: Not consuming alcohol, smoking, not exercising and being socially disadvantaged were related to high saturated fat intake and CHD death. Cox survival analyses adjusting for these factors found that a level of saturated fat 100 g per week higher corresponded to a relative risk for CHD death for men of 1.00 (0.86-1.18) and 1.40 (1.09-1.79) for women. This difference between the effects of saturated fat in men and women was statistically significant (P=0.019). Results are also reported for total fat and the relative effects of polyunsaturated and saturated fats. CONCLUSIONS: Strong evidence was found for the within cohort relationship of dietary fat and CHD death in women while no evidence was found for a relationship in men. Possible explanations for this are discussed.
OBJECTIVE: The paper aims to investigate the relationships of dietary fats to subsequent coronary heart disease (CHD) mortality in men and women while taking account of other CHD-related behaviours. DESIGN: A cohort of randomly selected men and women were interviewed in 1984-85 and monitored subsequently for 16 y for deaths. The interview covered health, health-related behaviours, physical measurements, socio-demographic details and a dietary questionnaire. Appropriate exclusions left 1225 men and 1451 women aged 40-75 with 98 and 57 CHD deaths, respectively. Saturated, polyunsaturated and total fat intakes were estimated. SETTING: The sample was randomly selected from households in Great Britain. The interviews took place in participants' own homes. RESULTS: Not consuming alcohol, smoking, not exercising and being socially disadvantaged were related to high saturated fat intake and CHD death. Cox survival analyses adjusting for these factors found that a level of saturated fat 100 g per week higher corresponded to a relative risk for CHD death for men of 1.00 (0.86-1.18) and 1.40 (1.09-1.79) for women. This difference between the effects of saturated fat in men and women was statistically significant (P=0.019). Results are also reported for total fat and the relative effects of polyunsaturated and saturated fats. CONCLUSIONS: Strong evidence was found for the within cohort relationship of dietary fat and CHD death in women while no evidence was found for a relationship in men. Possible explanations for this are discussed.
Authors: P Scully; P Tighe; G A Gilmore; J M W Wallace; J J Strain; H McNulty; M Ward; W S Gilmore Journal: J Thromb Thrombolysis Date: 2008-07-19 Impact factor: 2.300
Authors: Jennifer S Mindell; Simona Giampaoli; Antje Goesswald; Panagiotis Kamtsiuris; Charlotte Mann; Satu Männistö; Karen Morgan; Nicola J Shelton; W M Monique Verschuren; Hanna Tolonen Journal: BMC Med Res Methodol Date: 2015-10-05 Impact factor: 4.615
Authors: Russell J de Souza; Andrew Mente; Adriana Maroleanu; Adrian I Cozma; Vanessa Ha; Teruko Kishibe; Elizabeth Uleryk; Patrick Budylowski; Holger Schünemann; Joseph Beyene; Sonia S Anand Journal: BMJ Date: 2015-08-11