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Literature DB >> 1212207

An 18O double-labelling study of haemoglobin catabolism in the rat.

Abstract

The degradation of haemoglobin to bilirubin in the rat was investigated by 18O labelling of the molecular oxygen consumed by the animal. The oxygen atoms incorporated into bilirubin were derived from two different oxygen molecules. Implications of this finding for the mechanism of haem catabolism in vivo are discussed; both verdohaem and a dioxygen-bridged compound appear to be excluded at intermediates.

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Year: 1975 PMID： 1212207 PMCID： PMC1165773 DOI： 10.1042/bj1500565

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

5 in total

1. The preparation of crystalline bilirubin-C14.

Authors: J D OSTROW; L HAMMAKER; R SCHMID
Journal: J Clin Invest Date: 1961-08 Impact factor: 14.808

2. The formation of bilirubin from hemoglobin in vivo.

Authors: J D OSTROW; J H JANDL; R SCHMID
Journal: J Clin Invest Date: 1962-08 Impact factor: 14.808

Review 3. The degradation of haem by mammals and its excretion as conjugated bilirubin.

Authors: G H Lathe
Journal: Essays Biochem Date: 1972 Impact factor: 8.000

4. Enzymatic degradation of heme. Oxygenative cleavage requiring cytochrome P-450.

Authors: R Tenhunen; H Marver; N R Pimstone; W F Trager; D Y Cooper; R Schmid
Journal: Biochemistry Date: 1972-04-25 Impact factor: 3.162

5. The ready isomerization of bilirubin IX- in aqueous solution.

Authors: A F McDonagh; F Assisi
Journal: Biochem J Date: 1972-09 Impact factor: 3.857

5 in total

1. The mechanism of haem catabolism. A study of haem breakdown in spleen microsomal fraction and in a model system by 18O labelling and metal substitution.

Authors: R F King; S B Brown
Journal: Biochem J Date: 1978-07-15 Impact factor: 3.857

An 18O double-labelling study of haemoglobin catabolism in the rat.

1. The preparation of crystalline bilirubin-C14.

2. The formation of bilirubin from hemoglobin in vivo.

Review 3. The degradation of haem by mammals and its excretion as conjugated bilirubin.

4. Enzymatic degradation of heme. Oxygenative cleavage requiring cytochrome P-450.

5. The ready isomerization of bilirubin IX- in aqueous solution.

1. The mechanism of haem catabolism. A study of haem breakdown in spleen microsomal fraction and in a model system by 18O labelling and metal substitution.

2. Verdohemochrome IX alpha: preparation and oxidoreductive cleavage to biliverdin IX alpha.

3. A two-molecule mechanism of haem degradation.

4. Phycocyanobilin synthesis in the unicellular rhodophyte Cyanidium caldarium.

5. The mechanism of haem catabolism. Bilirubin formation in living rats by [18O]oxygen labelling.