Literature DB >> 12121965

Activities of ABT-773 against microaerophilic and fastidious organisms.

Sydney M Finegold1, Denise Molitoris, V T Phan, M-L Vaisanen, Hannah M Wexler.   

Abstract

ABT-773 was tested against 317 fastidious isolates; it inhibited 99% of organisms at a concentration of 4.0 microg/ml. With ampicillin-sulbactam and levofloxacin, only 2 and 6% of these strains, respectively, were resistant at the breakpoint. With clindamycin, penicillin G, and metronidazole, 22, 26, and 58% of the strains, respectively, were resistant.

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Year:  2002        PMID： 12121965      PMCID： PMC127350          DOI： 10.1128/AAC.46.8.2716-2719.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

Review 1.  ABT-773: a new ketolide antibiotic.

Authors:  T J Dougherty; J F Barrett
Journal:  Expert Opin Investig Drugs       Date:  2001-02       Impact factor: 6.206

2.  The in vitro activity of ABT773, a new ketolide antimicrobial agent.

Authors:  J M Andrews; T M Weller; J P Ashby; R M Walker; R Wise
Journal:  J Antimicrob Chemother       Date:  2000-12       Impact factor: 5.790

3.  In vitro activity of ABT-773 against anaerobic bacteria.

Authors:  E Sillerström; E Wahlund; C E Nord
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2000-08       Impact factor: 3.267

4.  Comparative in vitro activities of ABT-773 against aerobic and anaerobic pathogens isolated from skin and soft-tissue animal and human bite wound infections.

Authors:  E J Goldstein; D M Citron; C V Merriam; Y Warren; K Tyrrell
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

Review 5.  Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site.

Authors:  S Douthwaite; W S Champney
Journal:  J Antimicrob Chemother       Date:  2001-09       Impact factor: 5.790

6.  Comparative in vitro activities of ABT-773 against 362 clinical isolates of anaerobic bacteria.

Authors:  D M Citron; M D Appleman
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191
  6 in total

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