Literature DB >> 12121960

Extrusion of penem antibiotics by multicomponent efflux systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa.

Kiyomi Okamoto1, Naomasa Gotoh, Takeshi Nishino.   

Abstract

The high intrinsic penem resistance of Pseudomonas aeruginosa is due to the interplay among the outer membrane barrier, the active efflux system MexAB-OprM, and AmpC beta-lactamase. We studied the roles of two other efflux systems, MexCD-OprJ and MexXY-OprM, in penem resistance by overexpressing each system in an AmpC- and MexAB-OprM-deficient background and found that MexAB-OprM is the most important among the three efflux systems for extrusion of penems from the cell interior.

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Year:  2002        PMID： 12121960      PMCID： PMC127373          DOI： 10.1128/AAC.46.8.2696-2699.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.

Authors:  J R Aires; T Köhler; H Nikaido; P Plésiat
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

2.  Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay.

Authors:  K Okamoto; N Gotoh; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

3.  Antibacterial activity of WY-49605 compared with those of six other oral agents and selection of disk content for disk diffusion susceptibility testing.

Authors:  P C Fuchs; A L Barry; D L Sewell
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191

4.  Antibacterial activity of an oral penem, Sch 29482.

Authors:  H C Neu; P Labthavikul
Journal:  J Antimicrob Chemother       Date:  1982-02       Impact factor: 5.790

5.  Contribution of the MexX-MexY-oprM efflux system to intrinsic resistance in Pseudomonas aeruginosa.

Authors:  N Masuda; E Sakagawa; S Ohya; N Gotoh; H Tsujimoto; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

6.  Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Authors:  C K Stover; X Q Pham; A L Erwin; S D Mizoguchi; P Warrener; M J Hickey; F S Brinkman; W O Hufnagle; D J Kowalik; M Lagrou; R L Garber; L Goltry; E Tolentino; S Westbrock-Wadman; Y Yuan; L L Brody; S N Coulter; K R Folger; A Kas; K Larbig; R Lim; K Smith; D Spencer; G K Wong; Z Wu; I T Paulsen; J Reizer; M H Saier; R E Hancock; S Lory; M V Olson
Journal:  Nature       Date:  2000-08-31       Impact factor: 49.962

7.  Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.

Authors:  N Masuda; E Sakagawa; S Ohya; N Gotoh; H Tsujimoto; T Nishino
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

8.  Comparison of in vitro activity of FCE 22101, a new penem, with those of other beta-lactam antibiotics.

Authors:  R Wise; J M Andrews; G Danks
Journal:  Antimicrob Agents Chemother       Date:  1983-12       Impact factor: 5.191

9.  Comparative in-vitro activity of Sch 34343, a new penem antibiotic.

Authors:  D S Reeves; H A Holt; M J Bywater
Journal:  J Antimicrob Chemother       Date:  1985-06       Impact factor: 5.790

10.  The in-vitro activity of a novel penem FCE 22101 compared to other beta-lactam antibiotics.

Authors:  H C Neu; N X Chin; P Labthavikul
Journal:  J Antimicrob Chemother       Date:  1985-09       Impact factor: 5.790
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  12 in total

1.  The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model.

Authors:  Rebekah Henry; Bethany Crane; David Powell; Deanna Deveson Lucas; Zhifeng Li; Jesús Aranda; Paul Harrison; Roger L Nation; Ben Adler; Marina Harper; John D Boyce; Jian Li
Journal:  J Antimicrob Chemother       Date:  2015-01-14       Impact factor: 5.790

2.  In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.

Authors:  Malcolm G P Page; Clothilde Dantier; Eric Desarbre
Journal:  Antimicrob Agents Chemother       Date:  2010-03-22       Impact factor: 5.191

3.  Genomic Surveillance of Clinical Pseudomonas aeruginosa Isolates Reveals an Additive Effect of Carbapenemase Production on Carbapenem Resistance.

Authors:  Luke Diorio-Toth; Sidra Irum; Robert F Potter; Meghan A Wallace; Muhammad Arslan; Tehmina Munir; Saadia Andleeb; Carey-Ann D Burnham; Gautam Dantas
Journal:  Microbiol Spectr       Date:  2022-05-31

4.  The relative contribution of efflux and target gene mutations to fluoroquinolone resistance in recent clinical isolates of Pseudomonas aeruginosa.

Authors:  S A Dunham; C J McPherson; A A Miller
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-01-23       Impact factor: 3.267

Review 5.  Efflux-mediated drug resistance in bacteria.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2004       Impact factor: 9.546

6.  Berberine inhibits the MexXY-OprM efflux pump to reverse imipenem resistance in a clinical carbapenem-resistant Pseudomonas aeruginosa isolate in a planktonic state.

Authors:  Fen Su; Jiliang Wang
Journal:  Exp Ther Med       Date:  2017-11-01       Impact factor: 2.447

7.  Prevalence, antimicrobial susceptibility and virulotyping of Listeria species and Listeria monocytogenes isolated from open-air fish markets.

Authors:  Hossein Jamali; Mohammadjavad Paydar; Salmah Ismail; Chung Yeng Looi; Won Fen Wong; Behrad Radmehr; Atefeh Abedini
Journal:  BMC Microbiol       Date:  2015-07-25       Impact factor: 3.605

8.  Polyamino-Isoprenic Derivatives Block Intrinsic Resistance of P. aeruginosa to Doxycycline and Chloramphenicol In Vitro.

Authors:  Diane Borselli; Aurélie Lieutaud; Hélène Thefenne; Eric Garnotel; Jean-Marie Pagès; Jean Michel Brunel; Jean-Michel Bolla
Journal:  PLoS One       Date:  2016-05-06       Impact factor: 3.240

9.  Siderophore Cephalosporin Cefiderocol Utilizes Ferric Iron Transporter Systems for Antibacterial Activity against Pseudomonas aeruginosa.

Authors:  Akinobu Ito; Toru Nishikawa; Shuhei Matsumoto; Hidenori Yoshizawa; Takafumi Sato; Rio Nakamura; Masakatsu Tsuji; Yoshinori Yamano
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

10.  The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor.

Authors:  Hong-Ting Victor Lin; Teresa Massam-Wu; Chen-Ping Lin; Yen-Jen Anna Wang; Yu-Chi Shen; Wen-Jung Lu; Pang-Hung Hsu; Yu-Hou Chen; Maria Ines Borges-Walmsley; Adrian Robert Walmsley
Journal:  PLoS One       Date:  2017-09-12       Impact factor: 3.240
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