Literature DB >> 12121959

Two novel vaginal microbicides (polystyrene sulfonate and cellulose sulfate) inhibit Gardnerella vaginalis and anaerobes commonly associated with bacterial vaginosis.

Jose A Simoes1, Diane M Citron, Alla Aroutcheva, Robert A Anderson, Calvin J Chany, Donald P Waller, Sebastian Faro, Lourens J D Zaneveld.   

Abstract

This is the first report demonstrating the in vitro inhibitory activity of two novel microbicides (cellulose sulfate and polystyrene sulfonate) against bacterial vaginosis (BV)-associated bacteria. Vaginal application of these microbicides not only may reduce the risk of acquisition of human immunodeficiency virus and other sexually transmitted infection-causing organisms but may also decrease the incidence of BV.

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Year:  2002        PMID： 12121959      PMCID： PMC127353          DOI： 10.1128/AAC.46.8.2692-2695.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  Effect on normal vaginal flora of three intravaginal microbicidal agents potentially active against human immunodeficiency virus type 1.

Authors:  I J Rosenstein; M K Stafford; V S Kitchen; H Ward; J N Weber; D Taylor-Robinson
Journal:  J Infect Dis       Date:  1998-05       Impact factor: 5.226

2.  The effects of three nonoxynol-9 preparations on vaginal flora and epithelium.

Authors:  D H Watts; L Rabe; M A Krohn; J Aura; S L Hillier
Journal:  J Infect Dis       Date:  1999-08       Impact factor: 5.226

3.  The V3 region of the envelope glycoprotein of human immunodeficiency virus type 1 binds sulfated polysaccharides and CD4-derived synthetic peptides.

Authors:  D Batinić; F A Robey
Journal:  J Biol Chem       Date:  1992-04-05       Impact factor: 5.157

4.  Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition.

Authors:  H L Martin; B A Richardson; P M Nyange; L Lavreys; S L Hillier; B Chohan; K Mandaliya; J O Ndinya-Achola; J Bwayo; J Kreiss
Journal:  J Infect Dis       Date:  1999-12       Impact factor: 5.226

5.  Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens.

Authors:  B C Herold; A Siston; J Bremer; R Kirkpatrick; G Wilbanks; P Fugedi; C Peto; M Cooper
Journal:  Antimicrob Agents Chemother       Date:  1997-12       Impact factor: 5.191

6.  Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects.

Authors:  M K Stafford; H Ward; A Flanagan; I J Rosenstein; D Taylor-Robinson; J R Smith; J Weber; V S Kitchen
Journal:  J Acquir Immune Defic Syndr Hum Retrovirol       Date:  1998-04-01

7.  The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro.

Authors:  R Jennings; A Clegg
Journal:  J Antimicrob Chemother       Date:  1993-07       Impact factor: 5.790

8.  Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in Chiang Mai, Thailand.

Authors:  C R Cohen; A Duerr; N Pruithithada; S Rugpao; S Hillier; P Garcia; K Nelson
Journal:  AIDS       Date:  1995-09       Impact factor: 4.177

9.  Use of nonoxynol-9 and changes in vaginal lactobacilli.

Authors:  B A Richardson; H L Martin; C E Stevens; S L Hillier; A K Mwatha; B H Chohan; P M Nyange; K Mandaliya; J Ndinya-Achola; J K Kreiss
Journal:  J Infect Dis       Date:  1998-08       Impact factor: 5.226

10.  Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV.

Authors:  T E Taha; D R Hoover; G A Dallabetta; N I Kumwenda; L A Mtimavalye; L P Yang; G N Liomba; R L Broadhead; J D Chiphangwi; P G Miotti
Journal:  AIDS       Date:  1998-09-10       Impact factor: 4.177
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  16 in total

Review 1.  Role of heparan sulfate in sexually transmitted infections.

Authors:  Vaibhav Tiwari; Erika Maus; Ira M Sigar; Kyle H Ramsey; Deepak Shukla
Journal:  Glycobiology       Date:  2012-07-06       Impact factor: 4.313

2.  Differential Sensitivity of Lactobacillus spp. to Inhibition by Candidate Topical Microbicides.

Authors:  Robert A Anderson; Alla Aroutcheva; Kenneth A Feathergill; Amillia B Anderson
Journal:  Probiotics Antimicrob Proteins       Date:  2009-03-04       Impact factor: 4.609

3.  Polyethylene glycol-based hydrogels for controlled release of the antimicrobial subtilosin for prophylaxis of bacterial vaginosis.

Authors:  Sujata Sundara Rajan; Veronica L Cavera; Xiaoping Zhang; Yashveer Singh; Michael L Chikindas; Patrick J Sinko
Journal:  Antimicrob Agents Chemother       Date:  2014-02-24       Impact factor: 5.191

4.  Investigation of the physicochemical and physicomechanical properties of a novel intravaginal bioadhesive polymeric device in the pig model.

Authors:  Valence M K Ndesendo; Viness Pillay; Yahya E Choonara; Lisa C du Toit; Eckhart Buchmann; Leith C R Meyer; Riaz A Khan; Uwe Rosin
Journal:  AAPS PharmSciTech       Date:  2010-05-06       Impact factor: 3.246

5.  Development and characterization of bioadhesive vaginal films of sodium polystyrene sulfonate (PSS), a novel contraceptive antimicrobial agent.

Authors:  Sanjay Garg; Kavita Vermani; Alka Garg; Robert A Anderson; William B Rencher; Lourens J D Zaneveld
Journal:  Pharm Res       Date:  2005-04-07       Impact factor: 4.200

Review 6.  Vaginal microbicides and the prevention of HIV transmission.

Authors:  Blayne Cutler; Jessica Justman
Journal:  Lancet Infect Dis       Date:  2008-11       Impact factor: 25.071

7.  Single and multiple exposure tolerance study of polystyrene sulfonate gel: a phase I safety and colposcopy study.

Authors:  Christine K Mauck; Debra H Weiner; Susan A Ballagh; Mitchell D Creinin; David F Archer; Jill L Schwartz; Helen C Pymar; Jaim-Jou Lai; William F Rencher; Marianne M Callahan
Journal:  Contraception       Date:  2004-07       Impact factor: 3.375

Review 8.  A review of current intravaginal drug delivery approaches employed for the prophylaxis of HIV/AIDS and prevention of sexually transmitted infections.

Authors:  Valence M K Ndesendo; Viness Pillay; Yahya E Choonara; Eckhart Buchmann; David N Bayever; Leith C R Meyer
Journal:  AAPS PharmSciTech       Date:  2008-04-02       Impact factor: 3.246

9.  Polyanionic candidate microbicides accelerate the formation of semen-derived amyloid fibrils to enhance HIV-1 infection.

Authors:  Suiyi Tan; Lu Lu; Lin Li; Jixiang Liu; Yelena Oksov; Hong Lu; Shibo Jiang; Shuwen Liu
Journal:  PLoS One       Date:  2013-03-27       Impact factor: 3.240

10.  Feasibility of Repurposing the Polyanionic Microbicide, PPCM, for Prophylaxis against HIV Transmission during ART.

Authors:  Robert A Anderson; David Brown; Erin M Jackson; Kenneth A Feathergill; James W Bremer; Ralph Morack; Richard G Rawlins
Journal:  ISRN Obstet Gynecol       Date:  2010-11-28
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