Literature DB >> 12121944

Transport of an antifungal trypsin inhibitor isolated from corn across the blood-brain barrier.

William A Banks1, Michael L Niehoff, Robert L Brown, Zhi-Yuan Chen, Thomas E Cleveland.   

Abstract

We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 microl/g. min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.

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Year:  2002        PMID： 12121944      PMCID： PMC127332          DOI： 10.1128/AAC.46.8.2633-2635.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Cerebral aspergillosis in liver transplantation.

Authors:  A P Boon; D H Adams; J Buckels; P McMaster
Journal:  J Clin Pathol       Date:  1990-02       Impact factor: 3.411

2.  Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins.

Authors:  D Triguero; J Buciak; W M Pardridge
Journal:  J Neurochem       Date:  1990-06       Impact factor: 5.372

3.  Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data.

Authors:  C S Patlak; R G Blasberg; J D Fenstermacher
Journal:  J Cereb Blood Flow Metab       Date:  1983-03       Impact factor: 6.200

4.  Inhibition of plant-pathogenic fungi by a corn trypsin inhibitor overexpressed in Escherichia coli.

Authors:  Z Y Chen; R L Brown; A R Lax; T E Cleveland; J S Russin
Journal:  Appl Environ Microbiol       Date:  1999-03       Impact factor: 4.792

5.  Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

Authors:  W A Banks; L Ortiz; S R Plotkin; A J Kastin
Journal:  J Pharmacol Exp Ther       Date:  1991-12       Impact factor: 4.030

6.  Comparison of Kernel Wax from Corn Genotypes Resistant or Susceptible to Aspergillus flavus.

Authors:  J S Russin; B Z Guo; K M Tubajika; R L Brown; T E Cleveland; N W Widstrom
Journal:  Phytopathology       Date:  1997-05       Impact factor: 4.025

7.  A Corn Trypsin Inhibitor with Antifungal Activity Inhibits Aspergillus flavus alpha-Amylase.

Authors:  Z Y Chen; R L Brown; J S Russin; A R Lax; T E Cleveland
Journal:  Phytopathology       Date:  1999-10       Impact factor: 4.025

8.  Advances in the Development of Host Resistance in Corn to Aflatoxin Contamination by Aspergillus flavus.

Authors:  R L Brown; Z Y Chen; T E Cleveland; J S Russin
Journal:  Phytopathology       Date:  1999-02       Impact factor: 4.025

9.  Passage of pituitary adenylate cyclase activating polypeptide1-27 and pituitary adenylate cyclase activating polypeptide1-38 across the blood-brain barrier.

Authors:  W A Banks; A J Kastin; G Komaki; A Arimura
Journal:  J Pharmacol Exp Ther       Date:  1993-11       Impact factor: 4.030

10.  Aspergillosis of the central nervous system: clinicopathological analysis of 17 patients.

Authors:  T J Walsh; D B Hier; L R Caplan
Journal:  Ann Neurol       Date:  1985-11       Impact factor: 10.422
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3.  Gene expression profiling and identification of resistance genes to Aspergillus flavus infection in peanut through EST and microarray strategies.

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4.  Purification and Biochemical Characterization of a New Protease Inhibitor from Conyza dioscoridis with Antimicrobial, Antifungal and Cytotoxic Effects.

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