PURPOSE: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE). METHODS: The GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA). RESULTS: The hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF). CONCLUSIONS: These results suggest that these matrix components could be involved in the pathophysiology of TLE.
PURPOSE: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE). METHODS: The GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA). RESULTS: The hippocampus of TLEpatients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF). CONCLUSIONS: These results suggest that these matrix components could be involved in the pathophysiology of TLE.
Authors: Ling Zhu; Xiaoyu Liu; Daniel P Nemeth; Damon J DiSabato; Kristina G Witcher; Daniel B Mckim; Braedan Oliver; Xi Le; Gowthami Gorantla; Olimpia Berdysz; Jiaoni Li; Aishwarya D Ramani; Zhibiao Chen; Dongcheng Wu; Jonathan P Godbout; Ning Quan Journal: Brain Behav Immun Date: 2019-06-19 Impact factor: 7.217
Authors: Gaga Kochlamazashvili; Christian Henneberger; Olena Bukalo; Elena Dvoretskova; Oleg Senkov; Patricia M-J Lievens; Ruth Westenbroek; Andreas K Engel; William A Catterall; Dmitri A Rusakov; Melitta Schachner; Alexander Dityatev Journal: Neuron Date: 2010-07-15 Impact factor: 17.173
Authors: Wilhelm Hußler; Lukas Höhn; Christopher Stolz; Stefan Vielhaber; Cornelia Garz; Friedhelm C Schmitt; Eckart D Gundelfinger; Stefanie Schreiber; Constanze I Seidenbecher Journal: Front Cell Neurosci Date: 2022-04-11 Impact factor: 5.505