| Literature DB >> 12121073 |
Shigeru Kato1, Hui-Jun Yang, Takafumi Ueno, Shin-ichi Ozaki, George N Phillips, Shunichi Fukuzumi, Yoshihito Watanabe.
Abstract
The H64D/V68A and H64D/V68S mutants of Myoglobin are found to oxidize thioanisole with high enantioselectivity and reactivity. These mutants are also capable of enantioselective binding of alpha-methylbenzylamine, which mimics an expected sulfoxidation intermediate. The kinetic study of the amine binding shows that the Fe-O bond cleavage in the intermediate may be the chiral discrimination step of the sulfoxidation.Entities:
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Year: 2002 PMID： 12121073 DOI： 10.1021/ja0256414
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419