Literature DB >> 12121002

Transcriptomics and proteomics: tools for the identification of novel drug targets and vaccine candidates for tuberculosis.

Joanna C Betts1.   

Abstract

The availability of the complete genome sequence of Mycobacterium tuberculosis has revolutionised many areas of tuberculosis research and facilitated functional genomics studies. Most notably, transcriptomics and proteomics have become important tools in gaining increased understanding of the biology of M. tuberculosis and offer the promise of being able to deliver novel drug targets and vaccine candidates.

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Year:  2002        PMID： 12121002     DOI： 10.1080/15216540212651

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  14 in total

Review 1.  Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens.

Authors:  Aarti Rana; Shweta Thakur; Girish Kumar; Yusuf Akhter
Journal:  Front Genet       Date:  2018-11-27       Impact factor: 4.599

2.  Structure and Inhibitor Specificity of L,D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation.

Authors:  Kuppan Gokulan; Sangeeta Khare; Carl E Cerniglia; Steven L Foley; Kottayil I Varughese
Journal:  AAPS J       Date:  2018-03-09       Impact factor: 4.009

3.  Bioinformatics analysis of Brucella vaccines and vaccine targets using VIOLIN.

Authors:  Yongqun He; Zuoshuang Xiang
Journal:  Immunome Res       Date:  2010-09-27

4.  Potential Outer Membrane Protein Candidates for Vaccine Development Against the Pathogen Vibrio anguillarum: A Reverse Vaccinology Based Identification.

Authors:  Pallavi Baliga; Malathi Shekar; Moleyur Nagarajappa Venugopal
Journal:  Curr Microbiol       Date:  2017-11-08       Impact factor: 2.188

5.  Signature gene expression profiles discriminate between isoniazid-, thiolactomycin-, and triclosan-treated Mycobacterium tuberculosis.

Authors:  Joanna C Betts; Alistair McLaren; Mark G Lennon; Fiona M Kelly; Pauline T Lukey; Steve J Blakemore; Ken Duncan
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

6.  Vaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine development.

Authors:  Yongqun He; Zuoshuang Xiang; Harry L T Mobley
Journal:  J Biomed Biotechnol       Date:  2010-07-04

7.  Genomic Analysis of Pasteurella atlantica Provides Insight on Its Virulence Factors and Phylogeny and Highlights the Potential of Reverse Vaccinology in Aquaculture.

Authors:  Rebecca Marie Ellul; Panos G Kalatzis; Cyril Frantzen; Gyri Teien Haugland; Snorre Gulla; Duncan John Colquhoun; Mathias Middelboe; Heidrun Inger Wergeland; Anita Rønneseth
Journal:  Microorganisms       Date:  2021-06-04

8.  Genome-wide prediction of vaccine targets for human herpes simplex viruses using Vaxign reverse vaccinology.

Authors:  Zuoshuang Xiang; Yongqun He
Journal:  BMC Bioinformatics       Date:  2013-03-08       Impact factor: 3.169

9.  Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif.

Authors:  Viviane Villard; George W Agak; Géraldine Frank; Ali Jafarshad; Catherine Servis; Issa Nébié; Sodiomon B Sirima; Ingrid Felger; Myriam Arevalo-Herrera; Socrates Herrera; Frederic Heitz; Volker Bäcker; Pierre Druilhe; Andrey V Kajava; Giampietro Corradin
Journal:  PLoS One       Date:  2007-07-25       Impact factor: 3.240

10.  Characterization of Two Metal Binding Lipoproteins as Vaccine Candidates for Enterococcal Infections.

Authors:  Felipe Romero-Saavedra; Diana Laverde; Aurélie Budin-Verneuil; Cécile Muller; Benoit Bernay; Abdellah Benachour; Axel Hartke; Johannes Huebner
Journal:  PLoS One       Date:  2015-08-31       Impact factor: 3.240
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