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Literature DB >> 12120955

Lauric acid is desaturated to 12:1n-3 by hepatocytes and rat liver homogenates.

Philippe Legrand¹, Daniel Catheline, Vincent Rioux, Georges Durand.

Abstract

Lauric acid desaturation was investigated and described in liver homogenates and in cultured rat hepatocytes. The identification of the desaturated product of lauric acid has been performed using the oxidative cleavage method, and we showed that the obtained monoene was mainly 12:1n-3. This result suggests that lauric acid desaturation could be the first step in the biosynthesis of alpha-linolenic acid in animal cells.

Entities: Chemical Species

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Year: 2002 PMID： 12120955 DOI： 10.1007/s11745-002-0934-y

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

12 in total

1. Assay of proteins in the presence of interfering materials.

Authors: A Bensadoun; D Weinstein
Journal: Anal Biochem Date: 1976-01 Impact factor: 3.365

2. Myristic acid, unlike palmitic acid, is rapidly metabolized in cultured rat hepatocytes.

Authors: V Rioux; P Lemarchal; P Legrand
Journal: J Nutr Biochem Date: 2000-04 Impact factor: 6.048

3. Inhibiting delta9-desaturase activity impairs triacylglycerol secretion in cultured chicken hepatocytes.

Authors: P Legrand; D Catheline; M C Fichot; P Lemarchal
Journal: J Nutr Date: 1997-02 Impact factor: 4.798

4. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

Authors: H G Enoch; A Catalá; P Strittmatter
Journal: J Biol Chem Date: 1976-08-25 Impact factor: 5.157

8. The total synthesis and metabolism of 4-decenoate, dodeca-3,6-dienoate, tetradeca-5,8-dienoate and hexadeca-7,10-dienoate in the fat-deficient rat.

Authors: H Sprecher
Journal: Lipids Date: 1968-01 Impact factor: 1.880

Lauric acid is desaturated to 12:1n-3 by hepatocytes and rat liver homogenates.

1. Assay of proteins in the presence of interfering materials.

2. Myristic acid, unlike palmitic acid, is rapidly metabolized in cultured rat hepatocytes.

3. Inhibiting delta9-desaturase activity impairs triacylglycerol secretion in cultured chicken hepatocytes.

4. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

Review 5. The metabolism of polyenoic fatty acids.

6. Delta 8 desaturation in vivo of deuterated eicosatrienoic acid by mouse liver.

7. Synthesis of linoleate and alpha-linolenate by chain elongation in the rat.

8. The total synthesis and metabolism of 4-decenoate, dodeca-3,6-dienoate, tetradeca-5,8-dienoate and hexadeca-7,10-dienoate in the fat-deficient rat.

Review 9. Human milk in disease: lipid composition.

10. Hepatic delta 9 desaturation and plasma VLDL level in genetically lean and fat chickens.

Review 1. The complex and important cellular and metabolic functions of saturated fatty acids.