Literature DB >> 12120575

Oligodeoxynucleotides containing amide-linked LNA-type dinucleotides: synthesis and high-affinity nucleic acid hybridization.

Anne Lauritsen1, Jesper Wengel.   

Abstract

Synthesis of three different amide-linked LNA-type dinucleotides and their incorporation into 9-mer and 17-mer oligodeoxynucleotides is described; compared to the reference DNA-RNA duplex, incorporation of one of the three dimers (5'-DNA*LNA dimer) induced significantly increased duplex thermostabilities.

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Year:  2002        PMID： 12120575     DOI： 10.1039/b111000d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Methodological obstacles in knocking down small noncoding RNAs.

Authors:  Andreas Ploner; Christian Ploner; Melanie Lukasser; Harald Niederegger; Alexander Hüttenhofer
Journal:  RNA       Date:  2009-08-18       Impact factor: 4.942

2.  An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.

Authors:  Ysobel R Baker; Cameron Thorpe; Jinfeng Chen; Laura M Poller; Lina Cox; Pawan Kumar; Wooi F Lim; Lillian Lie; Graham McClorey; Sven Epple; Daniel Singleton; Michael A McDonough; Jack S Hardwick; Kirsten E Christensen; Matthew J A Wood; James P Hall; Afaf H El-Sagheer; Tom Brown
Journal:  Nat Commun       Date:  2022-07-12       Impact factor: 17.694

3.  Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications.

Authors:  Cameron Thorpe; Sven Epple; Benjamin Woods; Afaf H El-Sagheer; Tom Brown
Journal:  Org Biomol Chem       Date:  2019-05-29       Impact factor: 3.876
  3 in total

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