Literature DB >> 12120507

Development of therapeutics: opportunities within complementary and alternative medicine.

Linda W Engel1, Stephen E Straus.   

Abstract

Whereas other components of the National Institutes of Health support the discovery and subsequent development of novel chemical entities into drugs, the National Center for Complementary and Alternative Medicine (NCCAM) studies complex natural products that are marketed as dietary supplements. This article contrasts the regulatory framework for dietary supplements and drugs, outlines the challenges of evaluating dietary supplements for safety and clinical effectiveness, and describes the evolving drug model for botanicals.

Mesh：

Year:  2002        PMID： 12120507     DOI： 10.1038/nrd750

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  17 in total

1.  A survey of complementary and alternative medicine in Iran.

Authors:  Hassan Abolhassani; Mohsen Naseri; Sanam Mahmoudzadeh
Journal:  Chin J Integr Med       Date:  2012-07-22       Impact factor: 1.978

2.  Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers.

Authors:  Skyler B Johnson; Henry S Park; Cary P Gross; James B Yu
Journal:  JAMA Oncol       Date:  2018-10-01       Impact factor: 31.777

3.  Synergistic Anti-cancer Activity of MH-30 in a Murine Melanoma Model Treated With Cisplatin and its Alleviated Effects Against Cisplatin-induced Toxicity in Mice.

Authors:  Hae-Ran Park; Sung-Kee Jo; Hyang-Hee Cho; Uhee Jung
Journal:  In Vivo       Date:  2020 Jul-Aug       Impact factor: 2.155

4.  Chondroprotective potential of Phyllanthus amarus Schum. & Thonn. in experimentally induced cartilage degradation in the explants culture model.

Authors:  Waranee Pradit; Siriwadee Chomdej; Korakot Nganvongpanit; Siriwan Ongchai
Journal:  In Vitro Cell Dev Biol Anim       Date:  2014-12-17       Impact factor: 2.416

5.  Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.

Authors:  Shishir Shishodia; Gautam Sethi; Kwang Seok Ahn; Bharat B Aggarwal
Journal:  Biochem Pharmacol       Date:  2007-03-30       Impact factor: 5.858

6.  Ayurveda-modern medicine interface: A critical appraisal of studies of Ayurvedic medicines to treat osteoarthritis and rheumatoid arthritis.

Authors:  Arvind Chopra; Manjit Saluja; Girish Tillu
Journal:  J Ayurveda Integr Med       Date:  2010-07

7.  Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo.

Authors:  Kate Vandyke; Melanie Y White; Terry Nguyen-Khuong; Kim Ow; Sharon C-W Luk; Elizabeth A Kingsley; Alexandra Rowe; Shiu-Fun Pang; Bradley J Walsh; Pamela J Russell
Journal:  Neoplasia       Date:  2007-04       Impact factor: 5.715

8.  Pilot Study with regard to the Wound Healing Activity of Protein from Calotropis procera (Ait.) R. Br.

Authors:  Ramar Perumal Samy; Vincent T K Chow
Journal:  Evid Based Complement Alternat Med       Date:  2012-08-29       Impact factor: 2.629

9.  Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia.

Authors:  Siew Mooi Ching; Zainul Amiruddin Zakaria; Fuziah Paimin; Mehrdad Jalalian
Journal:  BMC Complement Altern Med       Date:  2013-06-26       Impact factor: 3.659

10.  Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice.

Authors:  Hae-Ran Park; Eun-Jin Ju; Sung-Kee Jo; Uhee Jung; Sung-Ho Kim; Sung-Tae Yee
Journal:  BMC Cancer       Date:  2009-03-17       Impact factor: 4.430
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