Literature DB >> 12119748

The impact of pharmacogenetics and pharmacogenomics on drug discovery.

Klaus Lindpaintner1.   

Abstract

It is widely perceived at present that pharmacogenetics and pharmacogenomics are about to revolutionize the face of medicine. In a more realistic assessment, the implementation of molecular genetics and biology will provide us with better ways to treat illnesses, and has already begun to do so in an incremental and evolutionary fashion. However, it is unlikely to change fundamentally the direction of medical progress. Advances are most likely to be made in the area of pharmacodynamics, as we learn to differentiate broader conventional clinical diagnoses into separate molecular subtypes.

Mesh:

Year:  2002        PMID: 12119748     DOI: 10.1038/nrd823

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  11 in total

1.  Expression profiling: fishing and chips.

Authors:  I P Hall
Journal:  Gut       Date:  2004-07       Impact factor: 23.059

Review 2.  Pharmacogenetics in the evaluation of new drugs: a multiregional regulatory perspective.

Authors:  Marc Maliepaard; Charity Nofziger; Marisa Papaluca; Issam Zineh; Yoshiaki Uyama; Krishna Prasad; Christian Grimstein; Michael Pacanowski; Falk Ehmann; Silvia Dossena; Markus Paulmichl
Journal:  Nat Rev Drug Discov       Date:  2013-02       Impact factor: 84.694

Review 3.  Using human genetics to improve safety assessment of therapeutics.

Authors:  Keren J Carss; Aimee M Deaton; Alberto Del Rio-Espinola; Dorothée Diogo; Mark Fielden; Diptee A Kulkarni; Jonathan Moggs; Peter Newham; Matthew R Nelson; Frank D Sistare; Lucas D Ward; Jing Yuan
Journal:  Nat Rev Drug Discov       Date:  2022-10-19       Impact factor: 112.288

Review 4.  Using pharmacogenetics and pharmacogenomics in the treatment of psychiatric disorders: some ethical and economic considerations.

Authors:  Katherine I Morley; Wayne D Hall
Journal:  J Mol Med (Berl)       Date:  2003-11-04       Impact factor: 4.599

Review 5.  Clinical translation of genotyping and haplotyping data: implementation of in vivo pharmacology experience leading drug prescription to pharmacotyping.

Authors:  Ioannis S Vizirianakis
Journal:  Clin Pharmacokinet       Date:  2007       Impact factor: 6.447

6.  Detecting imbalanced expression of SNP alleles by minisequencing on microarrays.

Authors:  Ulrika Liljedahl; Mona Fredriksson; Andreas Dahlgren; Ann-Christine Syvänen
Journal:  BMC Biotechnol       Date:  2004-10-22       Impact factor: 2.563

Review 7.  Translational biomarkers of acetaminophen-induced acute liver injury.

Authors:  Richard D Beger; Sudeepa Bhattacharyya; Xi Yang; Pritmohinder S Gill; Laura K Schnackenberg; Jinchun Sun; Laura P James
Journal:  Arch Toxicol       Date:  2015-05-17       Impact factor: 5.153

Review 8.  Phage Display Technology as a Powerful Platform for Antibody Drug Discovery.

Authors:  Kazuya Nagano; Yasuo Tsutsumi
Journal:  Viruses       Date:  2021-01-25       Impact factor: 5.048

Review 9.  Translating pharmacogenomics: challenges on the road to the clinic.

Authors:  Jesse J Swen; Tom W Huizinga; Hans Gelderblom; Elisabeth G E de Vries; Willem J J Assendelft; Julia Kirchheiner; Henk-Jan Guchelaar
Journal:  PLoS Med       Date:  2007-08       Impact factor: 11.069

Review 10.  Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery.

Authors:  Md Mirazul Islam; Zahurin Mohamed
Journal:  Biomed Res Int       Date:  2015-10-22       Impact factor: 3.411

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